Viral Nanotechnology

Viral Nanotechnology presents an up-to-date overview of the rapidly developing field of viral nanotechnology in the areas of immunology, virology, microbiology, chemistry, physics, and mathematical modeling. Its chapters are by leading researchers and practitioners, making it both a comprehensive and indispensable resource for study and research. The field of viral nanotechnology is new and quickly expanding due to increasing demand of the applications already developed. The editors identify viral nanotechnology as a significant science that concerns itself with how to use the molecular modules that the distinctly different science of molecular engineering only constructs. The current potential applications of viral technology are manifold, with opportunities to revolutionize practices in photonics, catalysis, electronics, energy, biomedicine, health care, and public health. This book emphasizes using viral nanotechnology to improve health. A special emphasis is placed upon using viral nanotechnology for developing vaccines. In addition, it documents viral nanotechnology’s use as a powerful tool for developing drugs and genetic therapies. There is also great potential in its use as a means for diagnostics, including the development of diagnostic reagents and novel imaging technologies for detecting disease and infectious agents. Viral nanotechnology’s rapid and exciting growth is due to the need for new tools in the prevention, diagnosis, and treatment of disease. The contributors to this volume approach each chapter with the hope that their research and practices will contribute to an improvement in health and life on an unprecedented scale in human history.

PrefaceEditorsContributorsIntroductionIntroduction to Capsid ArchitectureKaspars TarsSelf-Assembling Virus-like and Virus-Unlike ParticlesAdam Zlotnick, Samson Francis, Lye Siang Lee, and Joseph Che-Yen WangElectron Cryomicroscopy and Image Reconstruction of Viral NanoparticlesBettina BöttcherX-Ray Analysis of Viral NanoparticlesKaspars TarsComputational Methods for Engineering Protein 3D NanoobjectsJames Lara and Xiaojun XuViral Nanoparticles: Principles of Construction and CharacterizationAndris ZeltinsImmunology of Virus-like ParticlesMartin F. Bachmann and Franziska ZabelNanomedicine: General Considerations and ExamplesKenza Snoussi and Michael KannVirus-like Particles: A Versatile Tool for Basic and Applied Research on Emerging and Reemerging VirusesSandra Diederich, Alma Gedvilaite, Aurelija Zvirbliene, Andris Kazaks, Kestutis Sasnauskas, Nicholas Johnson, and Rainer G. UlrichVirus-like Particles Derived from Hepatitis VirusesWolfram H. GerlichHistory and Potential of Hepatitis B Virus Core as a VLP Vaccine PlatformHadrien Peyret, Sam Stephen, Nicola J. Stonehouse, and David J. RowlandsSplitCore: Advanced Nanoparticulate Molecular Presentation Platform Based on the Hepatitis B Virus CapsidPhilipp Kolb, Thi Thai An Nguyen, Andreas Walker, and Michael NassalUse of VLPs in the Design of Malaria VaccinesDavid Whitacre, Diego Espinosa, Darrell Peterson, Fidel Zavala, and David MilichUse of HBcAg as an Adjuvant in DNA-Based Vaccines: An Unexpected JourneyMatti SällbergBacteriophage Virus-like Particles as a Platform for Vaccine DiscoveryBryce Chackerian and David S. PeabodyProduction of Virus-like Particles in PlantsPooja Saxena and George P. LomonossoffBionanomaterials from Plant VirusesAlaa A.A. Aljabali and David J. EvansAssembly of Bluetongue Virus-like Particle: Multiprotein Complex and Its Use as VaccineAvnish Patel and Polly RoyVirus-like Particles Based on Polyomaviruses and Human Papillomaviruses as Vectors for Vaccines, Preventive and Therapeutic Immunotherapy, and Gene DeliveryTina DalianisApplications of Viral Nanoparticles Based on Polyomavirus and Papillomavirus StructuresJirina Suchanová, Hana Španielová, and Jitka ForstováNanoparticles of NorovirusMing Tan and Xi JiangVirus-like Particle Enzyme Encapsulation: Confined Catalysis and Metabolic MaterialsBenjamin Schwarz, Dustin Patterson, and Trevor DouglasPrinciples of Design of Virus Nanoparticles for Imaging ApplicationsIrina Tsvetkova and Bogdan DragneaEnveloped Viruses with Single-Stranded Negative RNA Genome as Objects and Subjects of VLP NanotechnologyPeter Pushko and Paul PumpensTraditional and Novel Trends in Influenza VaccinesPeter Pushko and Terrence M. TumpeyRetrovirus-Derived Virus-like ParticlesBertrand Bellier, Charlotte Dalba, and David KlatzmannCancer Therapy Applying Viral NanoparticlesKenneth LundstromAlphaviral Vectors for Cancer TreatmentAnna Zajakina, Jelena Vasilevska, Tatjana Kozlovska, and Kenneth LundstromSynthetic Virus-like Particles in Vaccine DesignArin Ghasparian and John A. RobinsonIndex

Yury Khudyakov, PhD, received his MS in genetics from Novosibirsk State University and his PhD in molecular biology from the D.I. Ivanovsky Institute of Virology, Academy of Medical Sciences in Russia. He is chief of the Molecular Epidemiology and Bioinformatics Laboratory, Division of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia. He has published more than 170 research papers and book chapters, is an author of several issued and pending patents, and is a member of the editorial board for the Journal of Clinical Virology and academic editor for PlosOne. Paul Pumpens graduated from the Chemical Department of the University of Latvia in 1970, received his PhD in molecular biology from the Latvian Academy of Sciences in Riga, and received his DSc from the Institute of Molecular Biology of the USSR Academy of Sciences in Moscow. He pioneered genetic engineering research in Latvia and was one of the first in the world to successfully clone the hepatitis B virus genome. He is an author of more than 300 scientific papers and issued or pending patents.