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This volume looks at classic and novel methods currently used by researchers to understand mood and anxiety disorders and foster precision medicine. Chapters in this book cover topics such as how the sucrose preference succeeds or fails as a measurement of anhedonia; fear conditioning in laboratory rodents; animal models for mania; rodent models for studying the impact of variation in early life mother-infant interactions on mood and anxiety; and prediction of susceptibility/resilience toward animal models of PTSD. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Comprehensive and cutting-edge, accommodating the novel views on how the neurobiology of psychiatric disorders should be reconceptualized, Psychiatric Vulnerability, Mood, and Anxiety Disorders: Tests and Models in Mice and Rats is a valuable resource for all researchers interested in learning more about this important and developing field.
1 Animal Models of Mood and Anxiety Disorders: The Pursuit of Standardization and Recognition of the Complex Neurobiology of Human Mental Health
Jaanus Harro
2 The Open Field Test
Vootele Võikar and S. Clare Stanford
3 The Light Dark Box Test in the Mouse
Solal Bloch and Catherine Belzung
4 The Olfactory Bulbectomized Rodent Remains a Valuable Preclinical Model of Depression and Antidepressant Activity
Michelle Roche and John P. Kelly
5 Marble-Burying in Mice
Jeffrey M. Witkin and Jodi L. Smith
6 How the Sucrose Preference Succeeds or Fails as a Measurement of Anhedonia
Tatyana Strekalova
7 A Vogel Conflict Test Using Food Reinforcement in Mice
Jeffrey M. Witkin and Jodi L. Smith
8 Fear Conditioning in Laboratory Rodents
Iris Müller and Markus Fendt
9 Learned Helplessness in Rodents
Kennia Moura Silveira and Sâmia Joca
10 Chronobiology of Mood States: Introducing Circadian Animal Models
Jorge Mendoza, Noëmi Billon, Guillaume Vanotti, and Viviane Pallage
11 Telemetry in Rats and Mice: Methodological Considerations and Example Studies of Stress and Anxiety in
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