Nanomaterials and Neoplasms Towards Clinical Applications

Nanomaterials have the potential to shift the paradigm for the diagnosis and treatment of many diseases, especially neoplasms, because of the intriguing behaviors associated with their unique size-/shape-influenced chemical, physical, and physiological features. Currently, there is a huge imbalance between the several nanoplatforms reported in the literature and the few ones approved for clinical applications. This disequilibrium affects, in particular, plasmonic nanomaterials, which present no approved platforms and few candidates in clinical trials. This trend can be reversed by promoting collaborations among scientists from different fields as well as by improving the multidisciplinary background of researchers interested in this area. This book is a collection of must-read peer-reviewed papers focusing on (i) the main behaviors of nanomaterials for nanomedicine, (ii) key features nanomaterials need for successful translation to the clinical setting, and (iii) market analysis of nanomaterials at the bedside or on the way. The main aim of this book is to offer a comprehensive point of view to students and researchers in order to promote the translation of new technologies to patients. It is a unique reference for advanced undergraduate- and graduate-level students of nanotechnology and researchers in materials science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in cancer theranostics.

Detecting and Destroying Cancer Cells in More Than One Way with Noble Metals and Different Confinement Properties on the Nanoscale Erik C. Dreaden and Mostafa A. El-SayedEngineered Nanoparticles for Drug Delivery in Cancer Therapy Tianmeng Sun, Yu Shrike Zhang, Bo Pang, Dong Choon Hyun, Miaoxin Yang, and Younan XiaRecent Progress in Cancer Thermal Therapy Using Gold Nanoparticles Nardine S. Abadeer and Catherine J. MurphyGold Nanomaterials at Work in Biomedicine Xuan Yang, Miaoxin Yang, Bo Pang, Madeline Vara, and Younan XiaThe Nanomedicines Alliance: An Industry Perspective on Nanomedicines Frank J. MalinoskiNanomedicine(s) under the Microscope Ruth Duncan and Rogerio GasparImaging Nano–Bio Interactions in the Kidney: Toward a Better Understanding of Nanoparticle Clearance Junqing Wang and Gang LiuNanomaterials for Theranostics: Recent Advances and Future Challenges Eun-Kyung Lim, Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh, and Kwangyeol LeeMetabolism of Nanomaterials in vivo: Blood Circulation and Organ Clearance Bing Wang, Xiao He, Zhiyong Zhang, Yuliang Zhao, and Weiyue Feng

Valerio Voliani is a researcher at the Center for Nanotechnology Innovation, Instituto Italiano di Tecnologia, Italy. He obtained his MSc in chemistry and PhD in molecular biophysics from the Scuola Normale Superiore, Pisa, Italy. His work mainly focuses on the translation of nonpersistent plasmonic nanomaterials to patients in order to promote efficient treatments for neoplasms and infectious diseases. His research interests are related to photothermal conversion, drug delivery, photoacoustic/ultrasound imaging, and combined therapies. Dr. Voliani is also actively engaged in scientific disseminations to students and the community.