The Transplantation and Replacement of Thoracic Organs The Present Status of Biological and Mechanical Replacement of the Heart and Lungs

It is a great pleasure for me to contribute a few words as an achieved by many heart transplant centers and the ever improving results of lung transplantation and the functioning of mechanical introduction to the second edition of this volume, first published in 1990 when it was edited by David Cooper and Dimitri cardiac assist devices. Novitzky. The first edition was, in fact, a greatly expanded The current editors bring a wealth of expertise and experience version of an even earlier volume Heart Transplantation, edited to their task, and have blended together absolutely superb con­ by David Cooper and Robert Lanza and published in 1984. This tributions by many of the world's experts in their fields. This first work, authored by members of the medical staff of Groote comprehensive and highly readable volume documents the Schuur Hospital and the University of Cape Town Medical present 'state of the art' in the field of transplantation and School, was, I believe, the first volume reviewing this relatively replacement of thoracic organs. It provides an invaluable and un­ new field of medicine. paralleled source of information for those concerned with heart and lung medicine or surgery, and is essential reading for all who The present volume, therefore, continues the documentation of wish to keep abreast of developments in this field.

Foreword; C. Barnard. Preface. Contributing Authors. Acknowledgements: Personal, Journals. 1: General Considerations of Thoracic Organ Transplantation. 1. The concept and diagnosis of brain death; E.G. Warner. 2. Medico-legal aspects; S.S. Sanbar. 3. Donor organ availability and transplant coordination; J.S. Chaffin, L. Mischke. 4. Selection and management of the donor; D.K.C. Cooper, I.L. Paradis. 5. Selection and evaluation of the potential thoracic organ transplant recipient general considerations; D.K.C. Cooper, et al. 6. Pretransplant immunological considerations; E.D. du Toit, et al. 7. Immunobiology of allograft destruction; M.H. Sayegh, D.R. Saloman. 8. Maintenance immunosuppressive drug therapy and potential major complications; K.L. Tyndall, D.K.C. Cooper. 9. Trends in immunosuppressive therapy with regard to cytolytic induction therapy and corticosteroid withdrawal; J.A. Kobashigawa. 10. Tacrolimus (FK506) in thoracic organ transplantation; J.S. Gammie, S.M. Pham. 11. Infection in patients undergoing thoracic organ transplantation: epidemiology, pathogenesis, and clinical management; S.J. Thaler, R.H. Rubin. 12. Malignant neoplasia in the immunocompromised patient; I. Penn. 13. Long-term management and late complications of the thoracic organ transplant recipient; D.P. Nelson, et al. 14. Psychiatric aspects; E.S. Nash, D.K.C. Cooper. 15. Medico-social aspects; W.D. Paris, et al. 16. Nutrition and diet; M. Kanoski. 17. A commentary on the quality of life after thoracic organ transplantation; M.M. Edgar. 2: Heart Transplantation. 18. Experimental development and early clinical experience; D.K.C. Cooper. 19. Selection and management of the potential candidate for cardiac transplantation; L.W. Stevenson. 20. The problem of pulmonary hypertension in the potential cardiac transplant recipient; J.M. Chen, R.E. Michler. 21. Mechanical circulatory support before heart transplantation; J.S. Sapirstein, W.E. Pae Jr. 22. Anaesthetic management, including cardiopulmonary bypass; J.V. Booth, et al. 23. Current techniques of myocardial protection for cardiac transplantation; S.Aziz, A.L. Panos. 24. Surgical technique of orthotopic heart transplantation. 1: Standard approach; D.K.C. Cooper. 25. Surgical technique of orthotopic heart transplantation. 2: Bicaval 'total' approach; G. Dreyfus. 26. Immediate postoperative care and potential complications; D.K.C. Cooper, N.M. Lidsky. 27. Physiology and pharmacology of the transplanted heart; J.B. Young. 28. Pathology of cardiac allograft rejection. 1: Vascular (microvascular); E.H. Hammond. 29.Pathology of cardiac allograft rejection. 2: Acute cellular; A.G. Rose. 30. Clinical diagnosis of acute rejection; M.R. Costanzo. 31. Treatment of cardiac allograft rejection; L.W. Miller. 32. Infection in relation to thoracic transplantation; K. Love. 33. Pathology of cardiac allograft vasculopathy (chronic rejection); A.G. Rose. 34. Pathogenesis of cardiac allograft vasculopathy (