Section 1: Biosynthesis of Growth Hormone and Insulin-like Growth Factor-I and Regulation of Their Secretion
Introduction
Chapter 1: Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion
Chapter 2: Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor
Section 2: Growth Hormone and Insulin-like Growth Factor-I and their Function at the Receptor Level
Chapter 3: Mechanisms of Signal Transduction Utilized by Growth Hormone
Chapter 4: Insulin-like Growth Factor-I and Its Binding Proteins: Regulation of Secretion and Mechanism of Action at the Receptor Level
Section 3: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System
Chapter 5: Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid
Chapter 6: Growth Hormone, Insulin, and Insulin-like Growth Factor-I: Do They Interact at the Blood-Brain Barrier?
Chapter 7: Growth Hormone and Insulin-like Growth Factors in the Central Nervous System: Localization in Mammalian Species
Chapter 8: Purification of Growth Hormone Receptors from Human Brain Tissues
Chapter 9: Growth Hormone Receptor Message in the Rat and Human Central Nervous System: Structure and Function
Section 4: Central Nervous System Action of Growth Hormone: Basic Studies Using Animal Models
Chapter 10: Interaction of Growth Hormone and Prolactin in Brain Circuits
Chapter 11: Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain
Chapter 12: Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions
Chapter 13: Rodent Models for the Study of the Role of Growth Hormone-Insulin-like Growth Factor-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction
Chapter 14: Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function
Chapter 15: Insulin-like Growth Factor-I and Neuroprotection
Section 5: Immediate and Long-Term Benefits on the Central Nervous System and Growth Hormone Replacement Therapy
Chapter 16: Quality of Life in Adult Growth Hormone Deficiency
Chapter 17: The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology
Chapter 18: Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality
Chapter 19: Psychological Importance to the Child of Growth Hormone Replacement
Chapter 20: Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations
Chapter 21: Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia
Chapter 22: Cognitive Status of Adult Growth Hormone (GH)-Deficient Patients and GH-Induced Neuropsychological Changes
Chapter 23: Growth Hormone and Insulin-like Growth Factor-I in Alzheimer's Disease
Section 6: Growth Hormone Replacement and Related Therapies in Central Nervous System Disorders: A Future Perspective
Chapter 24: Growth Hormone Antagonists: A Pharmacological Tool in Present and Future Therapies
Chapter 25: Growth Hormone Replacement Therapy and Life Quality: Future Perspectives
Index
