Regional Cancer Therapy

Regional cancer therapies remain important options in the management of malignant disease, in spite of the venue of more targeted agents for systemic therapies. New te- nologies and better guidance systems for radiofrequency ablation and intrastitial laser therapies, highly selective intravascular approaches with improved catheters and gu- ance systems, improved agents for embolizations, and new vasoactive drugs for isolated limb and liver perfusions are just a few of the new developments in a field that is alive and progressing. Regional Cancer Therapy, so well put together by the editors Peter M. Schlag and Ulrike S. Stein, presents an overview of today’s realities and tomorrow’s possibilities. Regional cancer therapy models provide ways to make new discoveries about tumor biology and new agents that may be used regionally as well as systemically. This book should therefore be of interest to all clinicians and scientists with an interest in tumor biology as well as clinical advances. Alexander M. M. Eggermont, MD, PhD Professor and Head of Surgical Oncology Erasmus University MC—Daniel den Hoed Cancer Center Rotterdam, the Netherlands v PREFACE The treatment of malignant tumors has been substantially improved in recent years due to developments in clinical medicine and technology as well as by advances in mole- lar biological research. Modern molecular and genetic techniques allow the charact- ization of molecules that are decisive for tumor development and progression.

Table of content: Regional Cancer Therapy Foreword/Preface Alexander M.M. Eggermont Part I. Background 1. Biological background: Multidrug resistance-clinical implications Ulrike S. Stein, Wolfgang Walther, and Peter M. Schlag 2. Pharmacological background Hans Gelderblom, Joost Rothbarth, Cornelius J.H. van de Velde, and Henk-Jan Guchelaar 3. Isolated limb and organ perfusion laboratory models Timo L.M. ten Hagen and Alexander M.M. Eggermont Part II. Techniques and prerequisites for regional therapy 1. Interventional radiotherapy Enrique Lopez Hänninen and Timm Denecke 2. Surgical strategies Sandra Grünberg and Peter M. Schlag 3. Regional thermotherapy Peter Wust and Johanna Gellermann 4. Radiofrequency thermal ablation Eren Berber and Allan E. Siperstein 5. Cryoablation for primary and secondary liver tumors Tristan D. Yan, Faruque Rriffat, and David L. Morris 6. A personal history of photodynamic therapy Thomas J. Dougherty 7. Ultrasound guided therapy Robert F. Wong, Amanjit S. Gill, and Manoop S. Bhutani 8. Nanocarriers and drug delivery Svetlana Gelperina 9. Local gene therapy for cancer Wolfgang Walther, Ulrike S. Stein, and Peter M. Schlag Part III. Indications and results for different tumor entities 1. Regional chemotherapy of primary and metastatic liver tumors Rebecca Taylor, James Tomlinson, and Nancy Kemeny 2. Focal liver ablation techniques in primary and secondary liver tumors Giuseppe Garcea and David P. Berry 3. Peritoneal surface oncology Yehuda Skornick and Paul H. Sugarbaker 4. Malignant peritoneal mesothelioma David P. Mangiameli, Steven K. Libutti, James F. Pingpank, and H. Richard Alexander 5. Regional therapy of pancreatic cancer Hiroshi Yoshida, Yasuhiro Mamada, Nobuhiko Taniai, Yoshiaki Mizuguchi, Tetsuya Shimizu, Yoshiharu Nakamura, Takayuki Aimoto, Eiji Uchida, and Takashi Tajiri 6. Regional breast cancer treatment Moshe Z. Papa and Siegel Sadetzki 7. Regional therapy in ovarian cancer Marcello Deraco, Francesco Raspagliesi, and Shigeki Kusamura 8. Regional therapy of tumors of the bladder Ingo Kausch and Dieter Jocham 9. Regional therapy of rectal cancer Stefano A. Guadagni, Mario Schietroma, Giammaria Fiorentini, Maurizio Cantore, Claudio Lely, Cristina Ruscitti, Marco Clementi, Evangelos Kanavos, and Gianfranco Amicucci 10. Percutaneous laser ablation of lung metastases Christiane Weigel, Claus-Dieter Heidecke, and Norbert Hosten 11. Regional therapy of brain tumors Andreas Jordan and Klaus Maier-Hauff 12. Hyperthermic intrapleural chemotherapy in pleural malignancy Frans A.N. Zoetmulder and Serge van Ruth 13. Isolated limb perfusion in advanced soft tissue sarcomas Peter M. Schlag and Per-Ulf Tunn 14. Isolated limb perfusion for melanoma intransit metastases Flavia Brunstein, Dirk J. Grünhagen, Timo ten Hagen, and