Radiopharmaceuticals A Guide to PET/CT and PET/MRI

This book provides a rapid and concise guide to PET (PET/CT and PET/MRI) molecular imaging, concentrating extensive information on PET radiopharmaceuticals in a single volume.

The book reflects the rapid development of several PET tracers over the last decade, as a result of which the “traditional” PET/CT with 18F-FDG, the “cornerstone” of PET imaging, is now only one of several available options, which use different tracers for different diseases. For the same reason, PET imaging is no longer limited to the field of oncology.

In the editors’ experience, students in medicine and residents in nuclear medicine and radiology have limited access to scientific papers concerning novel PET tracers. Moreover, these papers generally focus on a single PET radiopharmaceutical. With approx. 20 radiopharmaceuticals explained in detail and a wealth of images and clinical cases, the book represents a versatile, comprehensive and practice-oriented guide to PET imaging, pursuing a unique and novel approach to the clinical role of PET tracers.

The book’s didactic nature also makes it an invaluable tool for residents in nuclear medicine and radiology, as well as for radiographers and clinicians in radiotherapy, oncology, hematology, cardiology and neurology.

¹⁸F-FDG.- ¹⁸F-DOPA.- The lipogenesis pathway: radiolabeled choline.- ¹⁸F-FET.- ¹⁸F-NaF.- The Somatostatin Receptors Analogues (⁶⁸Ga-DOTATOC, ⁶⁸Ga-DOTANOC, ⁶⁸Ga-DOTATATE).- ⁶⁴Cu-radiopharmaceuticals.- Amyloid Imaging.- PET myocardial perfusion imaging: ⁸²Rb.- The bone pathway: 223Ra-dichloride.- ¹¹C-methionine.- ⁶⁸Ga-PSMA.- PET biomarkers for tau pathology.

Dr. Ferdinando Calabria graduated with a degree in Medicine in 2005 and specialized in Nuclear Medicine in 2009 at the University of Rome “Tor Vergata.” As a resident in Nuclear Medicine, he began studying the molecular pathways of new PET radiopharmaceuticals. His specific scientific interest was in deepening our knowledge of the physio-pathological features of PET radiopharmaceuticals bio-distribution in order to verify further diagnostic applications. Another topic during this period was the evaluation of the potential added value of rising hybrid imaging with SPECT/CT and PET/CT scanners. Since 2010 he has led the Department of Nuclear Medicine at Neuromed Research Institute, where he has focused on prostate cancer imaging with 18F-choline PET/CT and brain tumor imaging with 18F-DOPA PET/CT. In 2015 his scientific interest shifted to the imaging of the brain, working on a hybrid PET/MRI 3T scanner installed at the Italian National Research Council. Here, he started developing an interest in applying 18F-FDG PET/MRI for patients with neurodegenerative diseases and 18F-FET for neuro-oncology, using a multidisciplinary network approach. He is currently exploring the role of advanced hybrid imaging with SPECT/CT and PET/CT in oncological patients, at the national public Hospital “Mariano Santo” in southern Italy. The author of over 40 scientific papers listed in PubMed, he has also served as a reviewer for the major specialized scientific journals of nuclear medicine.

Prof. Orazio Schillaci graduated with a degree in Medicine in 1990 and specialized in Nuclear Medicine in 19942 at the University of Rome “La Sapienza.” He began his scientific work at the University of L’Aquila: during this important period, Schillaci started exploring molecular imaging, with an emphasis on SPECT for neuroendocrine tumors. After a research stay in California, USA, he became a Professor of Nuclear Medicine at the University of Rome “Tor Vergata” in 2001. Since 2008 he has led the School of Specialization in Nuclear Medicine and, since 2013, has been Director of the School Of Medicine at the “Tor Vergata” University Hospital in Rome. The author of more than 220 scientific articles listed in PubMed, his current research interest is in the development of novel PET radiopharmaceuticals and their potential clinical applications in oncology, neurology, cardiology and infectious disease, within a network involving several Italian and European institutions. Most recently, he became President of the Italian Association of Nuclear Medicine (AIMN).