Pvp A Critical Review of the Kinetics and Toxicology of Polyvinylpyrrolidone (Povidone)

Polyvinylpyrrolidone is widely used in medicine, pharmaceuticals, cosmetics, foods, printing inks, textiles, and many more diverse applications. This book describes the 50 years of research, published and unpublished, on the absorption, distribution, storage, and excretion of PVP. The toxicology of PVP is critically evaluated. The author's involvement in the recent reevaluation of PVP by the Joint Expert Committee on Food Additives of the World Health Organization (WHO) and the Food and Agriculture Organization (FOA) led them to undertake this comprehensive review of all the information on the subject. This book will be invaluable for anyone who is involved with polyvinylpyrrolidone. Included is a broad review of the toxicological studies performed on PVP, including acute, subchronic, chronic, reproductive, mutagenicity, and carcinogenicity studies. There is also an appendix listing the key studies, with references, on the absorption, renal elimination, distribution, acute toxicity, subchronic toxicity, chronic toxicity, teratogenicity, mutagenicity, and carcinogenicity of PVP.

1. Introduction 2. Synthesis and Properties of PVP 3. Movement of Large Molecules Across Membranes—General Considerations 4. Absorption of PVP by Various Routes of Administration 5. Excretion and Metabolism of PVP 6. Distribution and Storage of PVP 7. Storage of PVP in Humans 8. Functional Consequences of PVP Uptake by Body Tissues, with Particular Reference to the Reticuloendothelial System (RES) and the Immune System 9. Toxicological Studies on PVP 10. Overall Summary and Conclusions

Schwarz, Wolfgang