Precision Molecular Pathology Of Prostate Cancer - Robinson Brian D. (Curatore); Mosquera Juan Miguel (Curatore); Ro Jae Y. (Curatore); Divatia Mukul (Curatore) | Libro Springer 06/2019 - HOEPLI.it


home libri books ebook dvd e film top ten sconti 0 Carrello


Torna Indietro

robinson brian d. (curatore); mosquera juan miguel (curatore); ro jae y. (curatore); divatia mukul (curatore) - precision molecular pathology of prostate cancer

Precision Molecular Pathology of Prostate Cancer

; ; ;




Disponibilità: Normalmente disponibile in 15 giorni


PREZZO
135,98 €
NICEPRICE
129,18 €
SCONTO
5%



Questo prodotto usufruisce delle SPEDIZIONI GRATIS
selezionando l'opzione Corriere Veloce in fase di ordine.


Pagabile anche con 18App Bonus Cultura e Carta del Docente


Facebook Twitter Aggiungi commento


Spese Gratis

Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 06/2019
Edizione: Softcover reprint of the original 1st ed. 2018





Trama

This volume focuses on our current understanding of the molecular underpinnings of prostate cancer and their potential application for precision medicine approaches.  The emergence and applications of new technologies has allowed for a rapid expansion of our understanding of the molecular basis of prostate cancer and has revealed a remarkable genetic heterogeneity that may underlie the clinically variable behavior of the disease.  The book consists of five sections which provide insight about the following: (1) General principles; (2) Molecular signatures of primary prostate cancer; (3) Molecular signatures of advanced prostate cancer; (4) Key molecular pathways in prostate cancer development and progression; (5) and Precision medicine approach: Diagnosis, treatment, prognosis.  Precision Molecular Pathology of Prostate Cancer is an important resource for the practicing oncologist, urologist, and pathologist, and will also be useful for researchers in the prostate cancer community.  




Sommario

Part I. General principles.- Approach to patient.- Etiology.- Precursor and pre-invasive lesions of prostate cancer.- Prostatic adenocarcinoma: morphologic spectrum, Gleason scoring, etc.- Genetic susceptibility.- DNA damage repair, BRCA mutations, DNA adducts, SNPs.- Racial differences.- Cancer stem cells Part II. Molecular signatures of primary prostate cancer.- SNPs.- Copy number variation/chromosomal aberration (PTEN deletion, etc.).- Gene fusions (TMPRSS2:ERG, etc.).- Gene expression arrays.- Next generation sequencing (point mutations, indels, etc.).- Epigenetic changes (chromatin remodeling, etc.).- Proteomics.- Metabolomics.- miRNA and lncRNA Part III. Molecular signatures of advanced prostate cancer.- Lymph node metastasis.- Bone metastasis a.- RANKL, Src kinases, endothelins, bisphosphonates.- Visceral metastasis a.- Role of extracellular matrix, angiogenesis, epithelial-mesenchymal transition (EMT), inflammation.- Castration resistant prostate cancer (CRPC).- Neuroendocrine prostate cancer (NEPC) Part IV. Key molecular pathways in prostate cancer development and progression.- Androgen receptor in carcinogenesis.- Androgen receptor in progression (CRPC).- PI3K/Akt/mTOR/PTEN and ERK/MAPK pathways.- Cell cycle regulators (p53, etc.).- DNA damage repair.-         Tyrosine kinase signaling (EGFR, VEGFR, PDGFR, FGFR, IGFR, etc.).- Cytoskeletal function (microtubules and taxane therapy) Part V. Precision medicine approach: Diagnosis, treatment, prognosis.- Molecular diagnosis.- Molecular imaging.- Molecular prognostic markers/tests.- Molecular targeted therapies.- Towards molecular classification of prostate cancer.




Autore

Brian D. Robinson, MD
Weill Cornell Medicine
New York, NY
USA







i libri che interessano a chi ha i tuoi gusti





Altre Informazioni

ISBN:

9783319877211

Condizione: Nuovo
Collana: Molecular Pathology Library
Dimensioni: 235 x 155 mm Ø 1186 gr
Formato: Brossura
Illustration Notes:2 Illustrations, black and white
Pagine Arabe: 570
Pagine Romane: xiv






Utilizziamo i cookie di profilazione, anche di terze parti, per migliorare la navigazione, per fornire servizi e proporti pubblicità in linea con le tue preferenze. Se vuoi saperne di più o negare il consenso a tutti o ad alcuni cookie clicca qui. Chiudendo questo banner o proseguendo nella navigazione acconsenti all’uso dei cookie.

X