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safe stephen (curatore) - polychlorinated biphenyls (pcbs): mammalian and environmental toxicology

Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology




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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 11/2011
Edizione: Softcover reprint of the original 1st ed. 1987





Trama

Polychlorinated biphenyls (PCBs) have been produced commercially since be­ fore 1930. They proved to be highly versatile mixtures and their uses continued to expand during the early 1970's even after the unanticipated world-wide en­ vironmental contamination had been discovered (Jensen et aI. , 1969; Koeman et aI. , 1969). Over 600,000 metric-tons were produced and/or used in the U. S. during this time and it is estimated that worldwide production totaled about 1,200,000 metric-tons (Table 1). With low acute toxicities (Fishbein, 1974), these mixtures were considered gen­ erally biologically inactive even though industrial exposure had demonstrated he­ patic and dermatological effects (Fishbein, 1974; Hansen, 1987). Thus, use and disposal were not carefully monitored and it is estimated that one-third of the world-wide production of PCBs has been released into the global environment (Table 1). Table 1. Estimated production and disposition of PCBs b U. s. a Worldwide 6 6 Production/use 610 X 10 kg 1200 X 10 kg Mobil environmental reservoir 82 400 Static reservoirs In service 340 Dumps 130 Total static 470 800 a NAS, 1979 b Tatsukawa and Tanaba, 1984 2 Environmental Distribution Many countries now impose strict controls on the use and release of PCBs. Re­ lease into the environment has declined dramatically in the last decade, but con­ tinued release from reservoirs (Table 1) into burdened ecosystems (Table 2) ap­ pears inevitable for several more decades (Barros et aI. , 1984).




Sommario

Introductory Chapter: Polychlorinated Biphenyls: Environmental Occurrence and Analysis.- Environmental Toxicology of Polychlorinated Biphenyls.- Mammalian Biologic and Toxic Effects of PCBs.- Carcinogenic and Mutagenic Effects of PCBs.- Biotransformation of PCBs: Metabolic Pathways and Mechanisms.- Physiologic Pharmacokinetic Modeling of Polychlorinated Biphenyls.- PCBs and Human Health.










Altre Informazioni

ISBN:

9783642705526

Condizione: Nuovo
Collana: Environmental Toxin Series
Dimensioni: 244 x 170 mm
Formato: Brossura
Illustration Notes:X, 152 p.
Pagine Arabe: 152
Pagine Romane: x


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