Nutrition, Epigenetic Mechanisms, and Human Disease

As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as potent dietary signals regulating metabolic pathways and unmasks how susceptible genotypes are predisposed to diet-related diseases. Selected topics from this field have been covered in some books, but no other comprehensive text on epigenetics, nutrition, and human health and disease is available, until now. This book illustrates nutrition’s influence on epigenetic inheritance and the mechanisms underlying the modification of the metabolic imprint of an individual. This enriched understanding of nutrigenomics can be applied to master a tailored diet that can alleviate imprinted metabolic syndromes. Specifically, the book focuses on: Maternal, perinatal, and neonatal nutrition Epigenetic mechanisms and cancer Impacts of dietary factors, folate deficiency and DNA methylation Nutrition’s influence on genetic imprinting The basics of nutrigenomics and epigenetic regulation

PrefaceAcknowledgmentsThe EditorsContributors Nutritional Epigenetics and Disease Prevention: Are We There Yet?, Mukesh Verma Aging by Epigenetics: Nutrition, An Epigenetic Key to Long Life, Nilanjana Maulik and Gautam Maulik Folate and DNA Methylation, Julie Crowell, Anna Ly, and Young-In Kim Dietary Components, Epigenetics, and Cancer, Cindy D. Davis and Sharon A. Ross Dietary Factors, Histone Modifications, and Cancer Prevention, Igor P. Pogribny, Sharon A. Ross, and Igor Koturbash Nutrition, Epigenetics, and Vascular Function, M. Carey Satterfield, Jason R. McKnight, Xilong Li, and Guoyao Wu Role of Epigenetic Machinery and MicRNAs in Diet-Induced Hepatocarcinogenesis, Kalpana Ghoshal and Tasneem Motiwala Epigenetic Mechanisms in Lung Inflammation and Chronic Airway Diseases and Intervention by Dietary Polyphenols , Irfan Rahman Glycemic Memory and Epigenetic Changes, Andrew L. Siebel, Ana Z. Fernandez, and Assam El-Osta Maternal Nutrition, Intrauterine Development, and Disease Risks in the Offspring through Epigenetic Regulation of Gene Expression, Yuan-Xiang Pan, Rita Strakovsky, and Shasha Zheng Nutritional Epigenetics: Impact on Metabolic Syndrome, Lakshminarasimhan Pavithra, Sreenivas Chavali, and Samit Chattopadhyay Nutrition and the Emerging Epigenetic Paradigm: Lessons from Neurobehavioral Disorders, Axel Schumacher Interactions between Folate, Other B Vitamins, DNA Methylation, and Neurodevelopmental Disorders, Rebecca J. Schmidt and Janine M. LaSalle Dietary Factors and the Emerging Role of Epigenetics in Neurodegenerative Diseases, Lucia Migliore and Fabio Coppedè Index

Nilanjana Maulik is a Professor of Surgery at the Molecular Cardiology Angiogenesis Laboratory at the University of Connecticut School of Medicine. Gautam Maulik is an Instructor of Surgery at Brigham and Women's Hospital at Harvard Medical School.