Nucleoside Analogs in Cancer Therapy

Offering the most current and complete coverage of nucleoside analog activity in oncology and hematology, this single-source volume includes topics from pharmacology to previously unpublished clinical findings on the pivotal role of fludarabine, cladribine, and pentostatin in the management of diseases, such as chronic lymphocytic and hairy cell leukemia, non-Hodgkin's lymphoma, membranous nephropathy, and rheumatoid and psoriatic arthritis.

Nucleoside Analogs: Cellular Pharmacology, Mechanisms of Action, and Strategies for Combination Therapy, William Plunkett and Varsha GandhiInduction of Apoptosis by Nucleoside Analogs, Peng Huang and Susan WrightPharmacokinetics of Purine Nucleoside Analogs, Jan Liliemark and Gunnar JuliussonClinical Development of 2'-Deoxycoformycin, Bruce D. Cheson and Michael R. GreverClinical Development of Fludarabine, Axel-R. Hanauske and Daniel D. Von HoffDevelopment of 2-Chlorodeoxyadenosine (2-CdA) as a Chemotherapeutic and Immunosuppressive Drug, Ernest Beutler, Dennis Carson, Robert McMillan, and Robert LongmireDefining the Optimal Dose Schedule of Purine Analogs and Assessment of Response, Jorge E. Cortes and Susan M. O'BrienClinical Trials of the Purine Analogs in Chronic Lymphocytic Leukemia, Michael J. KeatingTreatment of Hairy Cell Leukemia with Nucleoside Analogs, Alan Saven and Lawrence D. PiroClinical Trials with Nucleoside Analogs in Lymphomas, Wolfgang Hiddemann and Christiane Pott-HoeckClinical Trials with Nucleoside Analogs in Other Hematologic Malignancies, Jorge E. Cortes, Hagop Kantarjian, Susan M. O'Brien, and Michael J. KeatingNucleoside Analogs as Radiosensitizing Agents, Vincent Grégoire and Walter N. Hittelman2-Chlorodeoxyadenosine in Nonmalignant Disorders, Ernest Beutler, Dennis Carson, J. C. Sipe, J. S. Romine, Robert McMillan, Z. M. Younossi, V. D. Rodgers, James A. Koziol, and J. ZyroffFludarabine in Nonmalignant Disorders, Ioannis O. Tassiulas, John C. Davis, Jr., Barri J. Fessler, Nobuaki Hama, Thomas A. Fleisher, Howard A. Austin III, and Dimitrios T. BoumpasToxicities Associated with Purine Analog Therapy, Bruce D. Cheson

Bruce D. Cheson (Edited by) , Michael J. Keating (Edited by) , William Plunkett (Edited by)