Nanoparticle-Based Drug Delivery in Cancer Treatment

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

Chapter 01 The advantages and versatility of carrier—free nanodrugs and nanoparticles systems for cancer therapy Chapter 02 Strategies, design, and chemistry in siRNA delivery vehicles systems for cancer therapy Chapter 03 DNA/RNA nanoparticles structures for siRNA deliver applications Chapter 04 Co-delivery in nanoparticle-based siRNA for cancer therapy Chapter 05 Small interfering RNAs (siRNAs), MicroRNAs and NPs in gynecological cancers Chapter 06 Nanoparticle–based RNA (siRNA) combination therapy toward overcoming drug resistance in cancer Chapter 07 Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications Chapter 08 Recent development of Silica nanoparticles as delivery biomedical applications for cancer imaging and therapy Chapter 09 Application of carbon nanotubes (CNTs) in cancer vaccines as drug delivery tools Chapter 10 Development of oligonucleotides delivery, (siRNAs), and (miRNA) systems for anticancer therapeutic strategy immunotherapy Chapter 11 Pharmacogenomics-synergistic strategies using a chimerical peptide for enhanced chemotherapy based on ROS and DNA nanosystem Chapter 12 Pharmacokinetics, biodistribution and therapeutic applications of recently-developed siRNA and DNA repair genes recurrence Chapter 13 Nanotechnologies assemblies of siRNA and chemotherapeutic drugs co-delivered for cancer therapeutic applications Chapter 14 Targeted systemic combinatorial delivery of siRNA polyplexes-Functional quantum dot-siRNA nanoplexes Chapter 15 Recent advances of nanotechnologies for cancer immunotherapy treatment List of Abbreviations

Prof. Loutfy H. Madkour is a professor of physical chemistry and nanoscience at Tanta University (Egypt). He received his BSc, MSc, and PhD in physical chemistry from the Cairo, Minia, and Tanta universities in Egypt, respectively. He has published 200 peer-reviewed original research articles, 20 review articles, and 8 books. He is an editorial board member of several international journals, including International Journal of Industrial Chemistry (IJIC-Springer), International Journal of Ground Sediment & Water, Global Drugs and Therapeutics, Chronicles of Pharmaceutical Science, Journal of Targeted Drug Delivery, UPI Journal of Pharmaceutical, Medical and Health Sciences, Global Journal of Nanomedicine, Clinical Pharmacology and Toxicology Research, Journal of Pharmacology & Pharmaceutical Research, LOJ Pharmacology & Clinical Research, CPQ Medicine, Pharmaceutical Sciences & Analytical Research Journal, Japan Journal of Research, Organic & Medicinal Chemistry International Journal, Nanotechnology & Applications, Materials Science Journal, Journal of Chemical Science and Chemical Engineering (Journals of– JCSCE), United Journal of Nanotechnology and Medicine, Clinical Practice (Therapy) journal, Journal of Materials New Horizons, Journal of Radiology and Medical Imaging. MedDocs Publishers, World Journal of Pharmacy and Pharmaceutical Sciences WJPPS and Journal of Material Science and Technology Research – RBM.