Melatonin Biosynthesis, Physiological Effects, and Clinical Applications

Melatonin: Biosynthesis, Physiological Effects, and Clinical Applications provides a thorough review of recent advances in major areas of melatonin research. The book is arranged in a logical sequence, beginning with the history of melatonin and then proceeding to cover its biochemistry and secretion, physiological effects, and clinical significance. New findings and current concepts are emphasized, and a significant amount of previously unpublished data are included. The book will be an important reference for neurobiologists, cell biologists, ophthalmologists, endocrinologists, neuroendocrinologists, reproductive biologists, psychiatrists, and other researchers and clinicians interested in melatonin.

Melatonin: History, Biosynthesis, and Assay Methodology (Hing-Sing Yu, Andrew T.C. Tsin, and Russel J. Reiter). Molecular Biology of the Pineal Gland: Melatonin Synthesizing Enzymes (Cheryl Craft). Multiple Pineal Receptors in Regulating Melatonin Synthesis (Manuchair Ebadi). Steroid Influences on Pineal Melatonin Production (Rafael Alonso, Pedro Abreu, and Natalia Fajardo). Regulation of Mammalian Pineal Melatonin Production by the Electromagnetic Spectrum (Russel J. Reiter and Alexander Lerchl). Melatonin Secretion and Its Rhythms in Biological Fluids (Shiu-Fun Pang, Peter P.N. Lee, Y.S. Chan, and Elizabeth A. Ayre). The Melatonin Receptor: Distribution, Biochemistry, and Pharmacology (Bojidar Stankov, Franco Fraschini, and Russel J. Reiter). Melatonin and Circadian Rhythmicity (Stuart M. Armstrong and Jennifer R. Redman). Melatonin and Seasonality in Mammals (Bruce Goldman and Randy J. Nelson). Melatonin and Reproduction in Sheep and Goats (Benoit Malpaux, Philippe Chemineau, and Jean Pelletier). Melatonin in Relation to the Immune System (Georges J.M. Maestroni and Ario Conti). Metabolic and Thyroid Consequences of Melatonin Administration in Mammals (Mary Vaughan and George Vaughan). Melatonin and Thermoregulation (Pietro Badia). Melatonin in the Eye: Functional Implications (Hing-Sing Yu). Melatonin and Its Synthetic Enzymes in Orbital Glands (Armando Menendez-Palaez and Russel J. Reiter). The Role of Melatonin in Human Pathophysiology (Derek Gupta). Melatonin in Oncology (David E. Blask). Circadian, Seasonal, Pineal, and Melatonin Influences on Epilepsy (Thomas H. Champney and Steven L. Peterson). Phototherapy and Melatonin in Relation to Seasonal Affective Disorder and Depression (Bjorn-Erik Thalén, Bengt Kjellman, and Lennert Wetterberg). Clinical Pharmacology of Melatonin Regulation (Lothar Demish).