Mechanisms of Intracellular Trafficking and Processing of Proproteins

Mechanisms of Intracellular Trafficking and Processing of ProProteins provides an in-depth discussion of the cellular organization and current views of the molecular mechanisms underlying the trafficking, sorting, and processing of various classes of proproteins. The book covers the mechanisms of pro-protein translocation across the rough endoplasmic reticulum (RER) membrane and subsequent transport to the Golgi apparatus, molecular sorting and retention signals involved in directing pro-proteins to various cellular compartments, and the specific enzymes mediating different posttranslational modification steps. It is the only book that covers the principles of intracellular trafficking and processing of proproteins using examples representative of different classes of proproteins in the cell. New classes of enzymes, especially proteases with unique specificities, are examined as well.Mechanisms of Intracellular Trafficking and Processing of ProProteins presents a wealth of information valuable to cell biologists, endocrinologists, neurobiologists, enzymologists, and biochemists. Students studying molecular endocrinology, neurobiology, and cell biology will also find the book to be a useful text.

Intracellular Protein Trafficking and Proprotein Processing: An Overview (H. Gainer). Intracellular Trafficking of Pre- (Pro) Proteins Across RER Membranes (W.R. Skach and V.R. Lingappa). Protein Transport from the Endoplasmic Reticulum to the Golgi Apparatus (C. Kaiser). Post-Translational Processing and Intracellular Transport of Newly Synthesized Lysosomal Enzymes (C.A. Gabel). Prohormone Processing: The Role of Propeptides in Intracellular Sorting, Precursor Processing, and Secretion (D. Shields and A. Danoff). Secretory Granule Formation (S.A. Tooze, E. Chanat, J. Tooze, and W.B. Huttner). Proteolytic Processing of Prohormones and Pro-Neuropeptides (Y.P. Loh, M.C. Beinfeld, and N.P. Birch). Endoproteolysis of Growth Factors and Other Nonendocrine Precursor Proteins (P.A. Bresnahan, J.S. Hayflick, S.S. Malloy, and G. Thomas). Processing of Pro-Peptides: Glycosylation, Phosphorylation, Sulfation, Acetylation, and Amidation (H.P.J. Bennett, A.F. Bradbury, W.B. Huttner, and D.G. Smyth).