Intraoperative Radiation Therapy

A comprehensive review of intraoperative radiation therapy, beginning with the rationale for innovative treatment and the radiobiology of single doses. Problems encountered in modifying a linear accelerator and a radiation therapy suite are reviewed in detail along with special problems relating to technology, nursing, anesthesiology, and various surgical subspecialties. Intraoperative radiation therapy applicators and dosimetric considerations are also reviewed. This text is a valuable reference tool for institutions planning to develop or construct intraoperative radiation therapy facilities.

1. History of Intraoperative Radiation Therapy 2. The Rationale for Intraoperative Radiotherapy 3. Radiobiology of Large Radiation Fractions 4. Application of Dose-Effect Relationships to Intraoperative Radiotherapy 5. Physical Aspects and Dosimetric Considerations for Intraoperative Radiation Therapy with Electron Beams 6. Physical Aspects of Intraoperative Radiation Therapy 7. Anesthesiologic Considerations for Intraoperative Radiation Therapy 8. Nursing and Technological Considerations in Intraoperative Radiation Therapy 9. The Development of an Intraoperative Radiation Therapy Program — The Groningen IORT Project 10. The Role of Orthovoltage Equipment for Intraoperative Radiation Therapy 11. The Use of Superficial X-Ray Equipment for Intraoperative Radiation Therapy 12. General Surgical Aspects of Intraoperative Radiation Therapy 13. Neurosurgical Considerations in Intraoperative Radiation Therapy 14. Intraoperative Radiation Therapy for Malignant Brain Tumors 15. Intraoperative Radiation Therapy for Advanced or Recurrent Head and Neck Malignancies 16. Intraoperative Radiation Therapy for Gastric Cancer 17. Intraoperative Radiation Therapy for Pancreatic Cancer in Japan 18. Intraoperative Radiation Therapy in Combination with Computer-Controlled Conformation Radiotherapy for Pancreatic Cancer 19. Intraoperative Radiation Therapy for Bladder Cancer 20. Intraoperative Radiation Therapy for Bladder Cancer: A Review of Techniques Allowing Improved Tumor Doses and Providing High Cure Rates without the Loss of Bladder Function 21. Intraoperative Radiation Therapy for Prostatic Cancer 22. Intraoperative Electron Beam Radiation Therapy for Gynecological Malignancies 23. Intraoperative Radiation Therapy for Colorectal Cancer 24. Intraoperative Radiation Therapy of Soft Tissue Sarcomas 25. Intraoperative Radiation Therapy at the Massachusetts General Hospital 26. Mayo Clinic Experience with Intraoperative and External Beam Irradiation with or without Resection 27. The Rus