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arber w.; schweiger h. g.; sela m.; syru?ek l.; vogt p. k.; henle w.; hofschneider p. h.; humphrey j. h.; jerne n. k.; koldovský p.; koprowski h.; maaløe o.; rott r. - current topics in microbiology and immunology / ergebnisse der mikrobiologie und immunitätsforschung

Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung Volume 70

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 11/2011
Edizione: Softcover reprint of the original 1st ed. 1975





Trama

The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double­ stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes­ viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor.




Sommario

Theoretical Aspects of Structure and Assembly of Viral Envelopes.- Latent Herpes Simplex Virus and the Nervous System.- Temperature-Sensitive Mutants of Herpesviruses.- Inhibition of the Multiplication of Enveloped Viruses by Glucose Derivatives.










Altre Informazioni

ISBN:

9783642661037

Condizione: Nuovo
Collana: Current Topics in Microbiology and Immunology
Dimensioni: 244 x 170 mm
Formato: Brossura
Illustration Notes:IV, 136 p.
Pagine Arabe: 136
Pagine Romane: iv


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