Cellular Therapy for Neurological Injury

Cellular Therapy for Neurological Injury discusses the current status of cellular therapy for neurological disorders. The primary areas of focus include traumatic brain injury, stroke (ischemic and hemorrhagic), and spinal cord injury. The book explores cell therapy approaches to these and other conditions, while discussing current advances and a literature review in the context of a field that is moving rapidly. The book presents a translational focus, addressing barriers and opportunities to moving forward. The mechanisms of injury are explored, as well as how these mechanisms influence the type of cell therapy used, the route of delivery, and dosing regimen. Written by leaders in the field, this is an invaluable resource for clinicians and researchers alike.

Acute Neurological Injury: Pathophysiology as Related to Therapeutic TargetsCharles S. Cox, Jr., Benjamin Aertker, and George P. LiaoOligodendrocyte Precursor Cells in Spinal Cord Injury RepairQi Lin CaoCell-Based Therapy for StrokeVivek Misra, Bing Yang, Sushil Sharma, and Sean I. SavitzExperimental Models of Traumatic Brain Injury: Clinical Relevance and ShortcomingsEdward W. Vogel III, Barclay Morrison III, Megan N. Evilsizor, Daniel R. Griffiths, Theresa C. Thomas, Jonathan Lifshitz, Richard L. Sutton, Joseph B. Long, David Ritzel, Geoffrey S.F. Ling, James Huh, Ramesh Raghupathi, and Tracy K. McIntoshBehavioral Testing after Experimental Traumatic Brain InjuryBridgette D. Semple and Linda J. Noble-HaeussleinTranslation Biomarkers for Traumatic Brain InjuryPramod K. Dash, Michael Hylin, and Anthony N. MooreNeuro-Immune Signaling Circuit in Traumatic Brain InjuryScott D. OlsonSoluble Factors and Mechanisms of Action of Mesenchymal Stem Cells in Traumatic Brain Injury and Organ Injury Induced by TraumaShibani Pati and Stuart L. GibbUse of a Natural Modulator of Inflammation (TSG-6) for the Therapy of Traumatic Brain InjuryDarwin J. ProckopTissue Engineering and Cell-Based Therapeutics for Repair of MyelomeningoceleKuoJen Tsao and Luke R. Putnam

Edited byCharles S. Cox, Jr., MD, University of Texas, Houston, USA