Blood and Marrow Transplant Handbook Comprehensive Guide for Patient Care

This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant and cellular therapy patients. 

Spanning the timeline from the initial consultation throughout the transplant process, this handbook begins by providing a general overview of stem cell transplantation and goes on to outline disease-specific indications for stem cell transplantation. It then focuses on transplant complications and ongoing care, and finally explores cellular therapies for hematologic malignancies.

Comprehensive and easy-to-use, Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care, Third Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers as well as residents, fellows, and other trainees who care for patients who undergo transplant and immune effector cell therapy.

Overview of Hematopoietic Stem Cell Transplantation & Cellular Therapy

The Business of Cellular Therapy and Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Sources and Donor Selection

Pre-transplant Assessment for Hematopoietic Stem Cell Transplantation Recipients and Donors

Social Work:  Evaluation and Social Supports

Conditioning Regimens

Physical and Occupational Therapy

Adolescent and Young Adult Concerns

Infection Prevention and Prophylaxis

Graft-versus-Host Disease (GvHD) Prophylaxis 

Transfusion Medicine

Anticoagulation and Antiplatelet Guidelines

Engraftment

Acute Myeloid Leukemia and Allogeneic Hematopoietic Stem Cell Transplant 

Acute Lymphoblastic Leukemia

Hodgkin Lymphoma and non-Hodgkin Lymphoma

Multiple Myeloma

HSCT for Germ Cell Tumors

Hematopoietic Stem Cell Transplant for Myelofibrosis

Chronic Myeloid Leukemia

Chronic Lymphocytic Leukemia

Hematopoietic Stem Cell Transplant for Severe Aplastic Anemia

Inherited Disorders

Hematopoietic Cell Transplant and Cellular Therapies for Sickle Cell Disease

Radiology Pearls for the Transplant Provider

Acute Graft-Versus-Host Disease (GvHD)

Immune Reconstitution

Infectious Complications 

Oral Complications

Gastrointestinal Complications

Pulmonary Complications

Cardiovascular Complications

Kidney Disease in Hematopoietic Stem Cell Transplantation

Neurological Complications

Endocrine Complications following Hematopoietic Stem Cell Transplantation

Thrombotic Microangiopathies

Women’s Health Care

Men’s Health for Bone Marrow Transplant Patients

Psychiatric Complications

Graft Failure

Second Primary Malignancies 

Relapse after Hematopoietic Stem Cell Transplantation

Safe Pain Management with Opioids in Post-Transplant Patients

Complementary Medicine: Acupuncture

Complementary Medicine

Complementary Medicine: Cannabinoids and the Hematopoietic Stem Cell Transplant (HSCT) Recipient

Management of Neurocognitive Effects and Fatigue During and After Stem Cell Transplant

Palliative Care

Long-Term Follow Up and Survivorship

CAR T Cells for Hematologic Malignancies

Natural Killer Cell Therapy in Allogeneic Stem Cell Transplant 

Mesenchymal stromal cells: Impact on hematopoietic cell transplantation

T cell Therapeutics: Donor Lymphocyte Infusion, Cytotoxic T Lymphocyte Infusion and Other Non-CAR T cell Therapies

Dendritic Cell Vaccines

BiTEs, DARTs and Peri-Transplant Minimal Residual Disease

CAR T Toxicity Management: Cytokine Release Syndrome and Neurotoxicity

Molecular testing for post-transplant surveillance 

Management of Immune Compromised Transplant and Immune Effector Cell Treated Patients in the Setting of the COVID-19 Viral Pandemic: the OHSU Experience

Appendix 2: Procedure - Bone Marrow Aspirate and Biopsy 

Appendix 3: Procedure - Lumbar Puncture 

Appendix 4: Procedure - Ommaya reservoir tap

Appendix 5: Procedure - Skin Biopsy 

Appendix 6: OHSU Food Safe Diet

Appendix 7: OHSU Low Bacteria Diet

Appendix 8: OHSU’s Graft-versus-host disease diet

Appendix 9:  OHSU vaccine guidelines

Appendix 10:  OHSU Donor and stem cell source selection in allogeneic hematopoietic progenitor cell transplantation

Richard T. Maziarz, MD

Professor of Medicine

Adult Blood and Marrow Stem Cell Transplant & Cell Therapy Program

Knight Cancer Institute

Oregon Health & Science University

Portland, OR 

USA

Susan Schubach Slater, BSN, MN, FNP-BC

Assistant Professor of Medicine

Adult Blood and Marrow Stem Cell Transplant & Cell Therapy Program

Knight Cancer Institute

Oregon Health & Science University

Portland, OR 

USA