Biopharmaceutics and Clinical Pharmacokinetics An Introduction, Fourth Edition,

For a decade and a half, Biopharmaceutics and Clinical Pharmacokinetics has been used in theclassrooms around the world as an introductory textbook on biophannaceutics and phannacokinetics.Now, the new Fourth Edition, Revised and Expanded further enhances the preceding editions'proven features, introducing significant advances in clinical pharmacokinetics, pharmacokineticdesign of drugs and dosage forms, and model-independent analyses.Still usable without prior knowledge of calculus or kinetics, this successfully implemented workbookmaintains a carefully graduated "building block" presentation, incorporating sample problemsand exercises throughout for a thorough understanding of the material.Biopharmaceutics and Clinical Pharmacokinetics features a growth-oriented format that systematicallydevelops and interrelates all subject matter .. . introduces basic theory and fields of application... emphasizes model-independent pharmacokinetic analyses ... presents biopharmaceutical aspectsof product design and evaluation .. . offers a unique approach to teaching dosage regimen design andindividualization . .. and considers structural modification of drug molecules for problems associatedwith pharmacokinetics.As a comprehensive coverage of the basic principles and the recent achievements in the field, noother textbook does as much for students of pharmacy, pharmacology, medicinal chemistry, andmedicine, or for scientists who desire a simple but thorough introduction to theory and application.

Introduction References Rates, Rate Constants, and Order Order Rates and Rate Constants Active and Passive Transport Introduction Passive Transport Active Transport References Pharmacokinetics Introduction Drug Disposition Constant-Rate Intravenous Infusion Compartmental Models and Their Limitations Absorption Rate Constants References Biopharmaceutics Extravascular Administration Absorption of Drugs from the Gastrointestinal Tract Factors Influencing Bioavailability Evaluation of the Bioavailability of a Single Drug Drug Delivery to Prolong Duration References Dosage Regimens Introduction Accumulation During Repetitive Dosing Adjustment of Dosage Regimen in Renal Failure Multiple Dosing of Constant-Rate Intravenous Infusions References Pharmacokinetic Aspects of Structural Modifications in Drug Design and Therapy Introduction Antimicrobial Agents Pharmacokinetics of Prodrugs Stereoisomers References Pharmacokinetic Applications in Clinical Practice Introduction Pharmacokinetic Drug Interactions Clinical Pharmacokinetics

Robert E. Notari