Biochemistry of Selenium

1. Forms of Selenium.- 1.1 Low Molecular-Weight Compounds.- 1.2 Macromolecular Forms of Selenium.- 11.11 References.- 2. Selenium Deficiency Diseases in Animals.- 2.1 Introduction.- 2.2 Dietary Liver Necrosis and Factor 3.- 2.3 Nutritional Muscular Dystrophy.- 2.4 Exudative Diathesis.- 2.5 Pancreatic Degeneration.- 2.6 Mulberry Heart Disease.- 2.7 Reproductive Problems.- 2.8 Myopathy of the Gizzard.- 2.9 Growth.- 2.10 Selenium—Responsive Unthriftiness of Sheep and Cattle.- 2.11 Periodontal Disease of Ewes.- 2.12 Encephalomalacia.- 11.11 References.- 3. Metabolism of Selenium.- 3.1 Absorption.- 3.2 Placental Transfer.- 3.3 Mechanism of the Antioxidant Action of Selenium.- 3.4 Effect of Paraquat.- 3.5 Effect on Cytochrome P-450.- 3.6 Selenium and Hepatic Heme Metabolism.- 11.11 References.- 4. Comparative Metabolism and Biochemistry of Selenium and Sulphur.- 4.1 Introduction.- 4.2 Comparative Metabolism of Selenium and Sulphur.- 4.3 Comparative Biochemistry of Selenium and Sulphur.- 11.11 References.- 5. Biological Interactions of Selenium with Other Substances.- 5.1 Cadmium.- 5.2 Arsenic.- 5.3 Copper.- 5.4 Silver.- 5.5 Cobalt.- 5.6 Manganese.- 5.7 Lead.- 5.8 Mercury.- 5.9 Thallium.- 5.10 Tellurium.- 5.11 Vanadium.- 5.12 Bismuth.- 5.13 Other Substances.- 11.11 References.- 6. Environmental Occurrence of Selenium.- 6.1 Geochemistry of Selenium.- 6.2 Soil Selenium.- 6.3 Uptake and Concentration of Trace Elements in the Roots, Stems, and Leaves of Plants.- 6.4 Forage Selenium.- 6.5 Selenium in Water.- 6.6 Selenium in Food.- 6.7 Intakes and Recommended Daily Allowance in Humans.- 6.8 Regulations in Regard to Animal Diets.- 11.11 References.- 7. Toxicity of Selenium.- 7.1 Introduction.- 7.2 Industrial Medical Aspects.- 11.11 References.- 8. Selenium in Health and Disease.-8.1 Selenium and Cancer.- 8.2 Selenium and Mutagenesis.- 8.3 Selenium and Immunity.- 8.4 Selenium and Dental Caries.- 8.5 The Anti-Inflammatory Properties of Selenium.- 8.6 Selenium and Heart Disease.- 8.7 Selenium and Aging.- 8.8 Cystic Fibrosis.- 8.9 Multiple Sclerosis.- 8.10 Cataracts.- 8.11 Other Diseases.- 8.12 Radioselenium as a Diagnostic Agent.- 11.11 References.- 9. Synthetic Forms of Selenium and Their Chemotherapeutic Uses.- 9.1 Anti-Infective Agents.- 9.2 Antifungal Agents.- 9.3 Antiparasitic Agents.- 9.4 Compounds Affecting the Central Nervous System.- 9.5 Compounds that Affect the Autonomic Nervous System.- 9.6 Compounds that Affect the Circulatory System.- 9.7 Anti-Inflammatory Compounds.- 9.8 Antihistamines.- 9.9 Anticancer Agents.- 9.10 Antiradiation Agents.- 9.11 Steroids.- 9.12 Selenocoenzyme A.- 9.13 Selenium-Containing Carbohydrates.- 9.14 Seleno-Amino Acids.- 11.11 References.- 10. Analytical Methods of Selenium Determination.- 10.1 Introduction.- 10.2 Sample Preparation and Storage.- 10.3 Destructive Analysis.- 10.4 Nondestructive Analysis.- References.