The Somatotrophic Axis in Brain Function

TRAMA

The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression. <BR>This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science. <BR>Contents are well balanced and cover a variety of relevant topics from basic to clinical research <BR>International selection of authors, with a good representation of the research on growth hormones <BR>A timely publication which will be useful to scientists in both basic and clinical research

SOMMARIO

Section 1: Biosynthesis of Growth Hormone and Insulin-like Growth Factor-I and Regulation of Their Secretion Introduction Chapter 1: Regulation and Mechanism of Growth Hormone and Insulin-like Growth Factor-I Biosynthesis and Secretion Chapter 2: Ghrelin, an Endogenous Ligand for the Growth Hormone Secretagogue Receptor Section 2: Growth Hormone and Insulin-like Growth Factor-I and their Function at the Receptor Level Chapter 3: Mechanisms of Signal Transduction Utilized by Growth Hormone Chapter 4: Insulin-like Growth Factor-I and Its Binding Proteins: Regulation of Secretion and Mechanism of Action at the Receptor Level Section 3: Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System Chapter 5: Growth Hormone and Insulin-like Growth Factor-I in Human Cerebrospinal Fluid Chapter 6: Growth Hormone, Insulin, and Insulin-like Growth Factor-I: Do They Interact at the Blood-Brain Barrier? Chapter 7: Growth Hormone and Insulin-like Growth Factors in the Central Nervous System: Localization in Mammalian Species Chapter 8: Purification of Growth Hormone Receptors from Human Brain Tissues Chapter 9: Growth Hormone Receptor Message in the Rat and Human Central Nervous System: Structure and Function Section 4: Central Nervous System Action of Growth Hormone: Basic Studies Using Animal Models Chapter 10: Interaction of Growth Hormone and Prolactin in Brain Circuits Chapter 11: Growth Hormone and Insulin-like Growth Factor-I and Cellular Regeneration in the Adult Brain Chapter 12: Growth Hormone and Insulin-like Growth Factor-I and Their Effects on Astroglial Gap Junctions Chapter 13: Rodent Models for the Study of the Role of Growth Hormone-Insulin-like Growth Factor-I or the Insulin Axis in Aging and Longevity: Special Reference to a Transgenic Dwarf Rat Strain and Calorie Restriction Chapter 14: Growth Hormone and Insulin-like Growth Factor-I and Their Interactions with Brain Circuits Involved in Cognitive Function Chapter 15: Insulin-like Growth Factor-I and Neuroprotection Section 5: Immediate and Long-Term Benefits on the Central Nervous System and Growth Hormone Replacement Therapy Chapter 16: Quality of Life in Adult Growth Hormone Deficiency Chapter 17: The Somatotropic Axis in Psychologic Functioning: Effects on Sleep and Psychopathology Chapter 18: Growth Hormone Replacement Therapy in Adults: Responsiveness Related to Life Quality Chapter 19: Psychological Importance to the Child of Growth Hormone Replacement Chapter 20: Acromegaly and Brain Function: Effects on the Human Brain during Conditions with Increased Growth Hormone Concentrations Chapter 21: Human Aging and the Growth Hormone/Insulin-like Growth Factor-I Axis: The Impact of Growth Factors on Dementia Chapter 22: Cognitive Status of Adult Growth Hormone (GH)-Deficient Patients and GH-Induced Neuropsychological Changes Chapter 23: Growth Hormone and Insulin-like Growth Factor-I in Alzheimer's Disease Section 6: Growth Hormone Replacement and Related Therapies in Central Nervous System Disorders: A Future Perspective Chapter 24: Growth Hormone Antagonists: A Pharmacological Tool in Present and Future Therapies Chapter 25: Growth Hormone Replacement Therapy and Life Quality: Future Perspectives Index

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9780120884841
• Collana: Academic Press
• Dimensioni: 279 x 216 mm
• Formato: Copertina rigida
• Illustration Notes: Illustrated
• Pagine Arabe: 384