Cortical Spreading Depression of Leao

TRAMA

This book focuses on energy metabolism and brain functions related to Cortical Spreading Depression of Leao (CSD), an important issue in brain pathophysiology. The first part of the book offers a comprehensive overview of the history and early research on CSD, and then discusses the recent advances in the technology used to map and monitor brain mitochondrial NADH redox state and other physiological functions during CSD. The chapters explore the connection between CSD and mitochondrial function under hypoxia, Ischemia and various drugs treatment, and provide a resource to scientists researching the development of CSD during various brain pathophysiological conditions.  This book is essential to scientists and students working in the field of bioenergetics of the brain and various organs and tissues in the body. The use of this technology is also crucial and applicable in the neuroscience field.

SOMMARIO

PrefaceFront Matter- Introduction and Historical Background       Aim of the bookLeão’s Cortical Spreading Depression (CSD)       Aristides Leão-life History       The Discovery of the “Spreading Depression”       Back to Brazil       Conclusion       Aristides Leão -The 4 Seminal Publications (1944-1947)       Oxygen Homeostasis in Tissues       The Discovery of Oxygen       The Discovery of the Mitochondrial Function        Monitoring of Mitochondrial Function In Vivo  Brain Energy Metabolism and Mitochondrial Function During CSD1.    Basic Principles and Technology of NADH and Multiparametric Monitoring Used in Studying Cortical Spreading Depression (CSD)1.1    Introduction1.2    From NADH Monitoring to Multiparametric Monitoring Systems1.2.1      Fiber Optic Based Fluorometer/Reflectometer1.2.2      Simultaneous Monitoring of NADH by DC-Fluorometer Reflectometer Together with Monitoring of Systemic Blood Pressure and Electro Cortical Activity (ECoG)1.2.3      Simultaneous Monitoring of NADH together with Extracellular K+, DC Steady Potential and ECoG1.2.4      Monitoring of Brain NADH Together with Tissue pO­­­2 and ECoG1.2.5      Multiparametric Assembly for Recording of NADH, Extracellular K+, H+, DC Steady Potential and ECoG1.2.5.1  Electrode Assembly1.2.5.2  Correction for Local DC Biopotential1.2.5.3 NADH Fluorescence Measurement1.2.6      Monitoring of NADH, pO2, Extracellular K+, DC and ECoG, Outside and Inside Hyperbaric Chamber 1.2.7      Simultaneous Real Time Monitoring of Brain NADH, HbO2, ECoG, DC Potential, Extracellular K+ and Ca2+1.2.8      Simultaneous Real Time Monitoring of Brain NADH, CBF, ECoG, DC Potential, Extracellular K+ and Ca2+1.2.9      Simultaneous Monitoring of Brain NADH, CBF, ECoG, DC Potential, Extracellular K+, Ca+2, H+1.2.10   Multiparametric Monitoring of Neurosurgical Patients1.2.11   Monitoring of the Mechanism of CSD Propagation1.2.12   Multisite Monitoring of NADH and DC Potential in Rats Under Various Conditions1.2.13   Multisite Multiparametric Monitoring of NADH, CBF and DC Potential in Rats Under Experimental Conditions2.    Single Point and Multisite monitoring of Brain NADH Fluorescence Under CSD2.1    Introduction2.2    Single Point Monitoring of NADH2.3    Two Point Monitoring of NADH2.4    Four Points Monitoring of NADH3.    Sequence of Physiological Responses and Sequence of Events Recorded During the CSD Cycle3.1    Introduction3.2    Effects of CSD on Cerebral Blood Flow and Brain Oxygen Consumption3.2.1 Introduction3.2.2 Methods3.2.3 Results3.2.4 Discussion3.3    Sequence of events recorded during the CSD cycle.3.3.1      The Use of the MPA System3.3.2      CSD Initiation and Contralateral Responses3.3.3      Discussion4.    Spontaneous Development of CSD Related to Brain Pathophysiological Condition4.1    Introduction4.2    During Anoxia, Hypoxia and Ischemia4.3    During Exposure to Hyperbaric Hyperoxia (HBO)4.3.1      First Study - HBO Effects on Mitochondrial NADH and ECoG4.3.1.1     Introduction4.3.1.2     Methodology4.3.1.3     Results4.3.1.4     Discussion4.3.2      Second Study - Protection against Oxygen Toxicity by Trimethadione (TMO)4.3.3      Third Study - Effects of CO2 under HBO4.3.4      Fourth Study - More Factors Affecting HBO Toxicity4.3.4.1     Effects of Pressure Level4.3.4.2     Effects of Age4.3.4.3     Effects of Anti-Epileptic Drugs4.3.5      Fifth Study - Multiparametric Monitoring of CSD Under HBO4.3.5.1     Introduction4.3.5.2     Methods4.3.5.3     Results4.3.5.4     Discussion4.4    During Drug Induced Seizure Activity4.5    Development of CSD During and After Traumatic Brain Injury4.5.1      First Study - Development of the TBI Model4.5.1.1     Introduction4.5.1.2     Technological Aspects4.5.1.3     Results4.5.1.4     Discussion4.5.2      Second Study - Level of ICP and CSD after TBI4.5.2.1     Introduction4.5.2.2     Methods4.5.2.3     Results4.5.2.4     Discussion5.    The Effects of Brain Metabolic and Other Perturbations on the Responses to Induced CSD5.1.   Effect of Oxygen Availability5.1.1      Introduction5.1.2      Effects of Hypoxia and Normobaric Hyperoxia 5.1.3      Responses to CSD Under Ischemia5.1.4      Responses to CSD Under Partial Ischemia - Statistical Analysis5.2    Effect of anesthesia on the responses to CSD5.3    Effects of hypothermia on the responses to CSD5.3.1      Introduction5.3.2      Our studies5.4    Responses to CSD in the Aging Rat6.    Effects of Pharmacological Agents on CSD6.1    Effects of Carbon Monoxide6.1.1 First Study - Hyperbaric Oxygenation and CO Intoxication6.1.1.1     Introduction6.1.1.2     Methods6.1.1.3     Results and Discussion6.1.2      Second Study-Multiparametric Monitoring During CO Exposure6.1.2.1     Introduction6.1.2.2     Methods6.1.2.3    

AUTORE

Dr. Avraham Mayevsky is a Professor Emeritus in The Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel. Dr Avraham Mayevsky's field of research since they started their Post-Doc training with Prof. Britton Chance in 1972, was Energy metabolism, including mitochondrial function in vivo, of the brain mainly and other tissues In Vivo, exposed to various pathophysiological conditions. During the 50 years of activity they were able to accomplish a large number of goals that have a very significant impact on the understanding of pathophysiological processes in the brain and other organs evaluated under In Vivo conditions. His vision was to develop experimental approaches and tools that will enable them to study various physiological processes in experimental animals and at the same time, will be ready for clinical applications. During the years Dr Mayevsky's laboratory published more than 60 papers dealing with the subject of Cortical Spreading Depression of Leao (CSD). Dr. Judith Sonn was a part of the Mina & Everard Goodman Faculty of Life Sciences and the Leslie and Susan Gonda Multidisciplinary Brain Research Center at Bar-Ilan University in Ramat-Gan, Israel, for 45 years and retired in 2017. After graduation, Dr Judith Sonn was a laboratory Manager in Prof. Joseph Kedem’s laboratory, which investigated the physiology of the cardiovascular system. She continued to study for the master’s degree under the supervision of Professor Kedem. The M.Sc. thesis (1979, Summa Cum Laude) was "Oxygen Balance in the Myocardium". This research approach helped to evaluate the myocardial oxygen balance In-Vivo which was described in about 15 articles. In 1991 Dr Judith Sonn joined Professor Avraham Mayevsky’s research team and as a Ph.D. student under his Supervision. The Doctoral dissertation (1996) was “Effect of Spreading Depression on the Interrelation Between Brain Energy Metabolism and Ion Homeostasis In-Vivo”.  During that time, they published 28 articles on the CSD subject.

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9783031080678
• Dimensioni: 235 x 155 mm Ø 828 gr
• Formato: Copertina rigida
• Illustration Notes: XXI, 420 p. 242 illus., 58 illus. in color.
• Pagine Arabe: 420
• Pagine Romane: xxi