Activity-Based Protein Profiling

TRAMA

This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.

SOMMARIO

Activity-based protein pro?ling – enabling multimodal functional studies of microbial communities.- Activity-Based Protein Pro?ling Methods to Study Bacteria: The Power of Small-Molecule Electrophiles.- Opportunities and Challenges in Activity-Based Protein Pro?ling of Mycobacteria.- Activity-Based Protein Pro?ling at the Host–Pathogen Interface.- Chemical Proteomic Pro?ling of Protein Fatty-Acylation in Microbial Pathogens.- How to Target Viral and Bacterial Effector Proteins Interfering with Ubiquitin Signaling.- ABPP and Host–Virus Interactions.- Activity-Based Protein Pro?ling for the Study of Parasite Biology.- Deciphering T Cell Immunometabolism with Activity-Based Protein Pro?ling.- Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.- Development of Activity-Based Proteomic Probes for Protein Citrullination.- Recent Advances in Activity-Based Protein Pro?ling of Proteases.- Opportunities for Lipid-Based Probes in the Field of Immunology.- Activity-Based Protein Pro?ling of Non-ribosomal Peptide Synthetases.- Target Identi?cation of Bioactive Covalently Acting Natural Products.- Applications of Reactive Cysteine Pro?ling.

AUTORE

Benjamin F. Cravatt, Ph.D. Department of Chemistry The Scripps Research Institute La Jolla, CA, USA cravatt@scripps.edu   Ku-Lung Hsu Ph.D. University of Virginia School of Medicine Department of Chemistry Charlottesville, VA, USA kh4ch@virginia.edu   Eranthie Weerapana Ph.D. Boston College Merkert Chemistry Chestnut Hill, MA, USA eranthie@bc.edu

ALTRE INFORMAZIONI

• Condizione: Nuovo
• ISBN: 9783030111427
• Collana: Current Topics in Microbiology and Immunology
• Dimensioni: 235 x 155 mm
• Formato: Copertina rigida
• Illustration Notes: X, 417 p. 115 illus., 70 illus. in color.
• Pagine Arabe: 417
• Pagine Romane: x