The Geometric Induction of Bone Formation

The Geometric Induction of Bone Formation describes new biomimetic biomaterials that offer mechanistic osteogenic surfaces for the autonomous and spontaneous induction of bone formation without the addition of osteogenic soluble molecular signals of the transforming growth factor-ß supergene family. The chapters frame our understanding of regenerative medicine in primate species, including humans. The goal is to unravel the fundamental biological mechanisms of bone formation unique to non-human and human primates. The broad target audience dovetails with several disciplines both in the academic and private biotech sectors primarily involved in molecular biology, tissue biology, tissue engineering, biomaterial science, and reconstructive, orthopedic, plastic, and dental surgery. Key Features Includes outstanding images of undecalcified whole mounted sections Summarizes non-human primate research – ideal for clinical translation Reviews methods for creating devices capable of making bone autonomously, i.e. an intrinsically osteo-inductive bioreactor and/or biomaterial Describes the spontaneous induction of bone formation including a whole spectrum of tissue biology, from basic molecular biology to clear-cut morphology and pre-clinical application in non-human primate species Intended for audiences in both academic research and the biotech industry

Preface/Introduction The Geometric Induction of Bone Formation Ugo Ripamonti and Hari A Reddi Chapter 1 The New Frontiers in Bone Tissue Engineering: Functionalized Biomimetic Surfaces beyond Morphogens and Stem Cells Ugo Ripamonti and Laura C. Roden Chapter 2 The Induction of Bone Formation: When and Why Bone Forms and Sometime Repair and Regenerate: The Enigmatic Myth of Bone Tissue Engineering and the Dream of Regenerative Medicine Ugo Ripamonti Chapter 3 The Induction of Bone Formation and the Osteogenic Proteins of the Transforming Growth Factor-ß Supergene Family: Pleiotropism and Redundancy Ugo Ripamonti Chapter 4 Coral-Derived Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation in Heterotopic Extraskeletal Sites: Morphological Time Studies Ugo Ripamonti Chapter 5 Concavities of Crystalline Sintered Hydroxyapatite-Based Macroporous Bioreactors Initiate the Spontaneous Induction of Bone Formation Ugo Ripamonti Chapter 6 Molecular Pathways Regulating the Geometric Induction of Bone Formation: Synthetizing and Embedding Osteogenic Proteins into Nanotopographic Geometries Raquel Duarte and Ugo Ripamonti Chapter 7 The Spontaneous Induction of Bone Formation by Intrinsically Osteoinductive Bioreactors for Human Patients: Osteoinductive Hydroxyapatite-Coated Titanium Implants Ugo Ripamonti

Ugo Ripamonti is a leader in the field of tissue induction and differentiation in postnatal osteogenesis. His principal achievement is the demonstration of the induction of bone formation in non-human primate models. In 1994 he was appointed professor at the Medical School University of the Witwatersrand, Johannesburg, in South Africa, leading its newly founded Bone Research Laboratory. He has written more than 200 publications, given more than 120 invited lectures at international symposia, and organized a series of workshops and symposia at the World Biomaterials Congresses and the International Conferences on Bone Morphogenetic Proteins.