Organ Specific Drug Delivery and Targeting to the Lungs

Organ Specific Drug Delivery and Targeting to the Lungs provides up to date information on the multidisciplinary field of particle engineering and drug delivery to the lungs, including advancements of nanotechnology. The text presents a unique, pragmatic focus with case studies, that help translate scientific understanding to practical implementation. In addition to highlighting the successful case studies, it also offers practical advice on watchouts, limitations, and ‘bookend’ boundaries involved in the stages of testing and development. Additional Features Include: Provides an account of particle engineering, discovery, biology, development, and delivery in relation with the advancements of nanotechnology, unlike any previous book. Brings together the leading experts and researchers in the field to critically assess and discuss various topics influencing drug delivery. Highlights the interplay of different scientific disciplines and the balance of requirements that are critical to molecule and product design. With the strategic focus on what matters during new product development, this book provides a guide to understanding and navigating new drug discovery and development for lung targets.

Chapter 01 Estimating Clinically Relevant Measures of Inhaled Pharmaceutical Aerosol Performance with Advanced In Vitro and In Silico Methods Chapter 02 In Vitro Assessment of Drug Release, Dissolution, and Absorption in the Lung Chapter 03 Lung-on-a-Chip and Lung Organoid Models Chapter 04 Interaction between Inhalable Nanomedicines and Pulmonary Surfactant Chapter 05 Particle engineering for pulmonary drug delivery Chapter 06 Particle Architectonics for Pulmonary Drug Delivery Chapter 07 Engineered Particles for Aerosolisation and Lung Deposition Chapter 08 Recent advances in inhalable nanomedicine for lung cancer therapy Chapter 09 Thin-Film Freeze-Drying Process for Versatile Particles for Inhalation Drug Delivery Chapter 10 Nanoparticles as specific drug carriers Chapter 11 Surface modification of micronized drug particles for aerosolization Chapter 12 Spray Dried Particles for Inhalation Chapter 13 Inhalation Aerosol Phospholipid Particles for Targeted Lung Delivery Chapter 14 Nebulizers Chapter 15 Protein and Peptide Delivery to the Lung via Inhalation Chapter 16 Exosomes Based Drug Delivery for Lung Cancer Treatment

Ajit S. Narang works for the Department of Pharmaceutical Sciences at ORIC Pharmaceuticals, Inc., in South San Francisco, CA. His primary expertise is in oral drug delivery. He holds over 20 years of pharmaceutical industry experience in drug development. Prior to ORIC, Ajit has also worked for Genentech, Inc.; Bristol-Myers Squibb, Co.; Ranbaxy Research Labs (currently a subsidiary of Daiichi Sankyo, Japan); and Morton Grove Pharmaceuticals (currently, Wockhardt USA). He holds undergraduate Pharmacy degree from the University of Delhi, India and graduate degrees in Pharmaceutical Sciences from the Banaras Hindu University, India, and the University of Tennessee Health Science Center (UTHSC) in Memphis, TN. He currently serves as the Chair of Biopharmaceutics Technical Committee of the Product Quality Research Institute. His current research interests focus on new drug discovery research. He has been credited with several publications, patents, and books throughout his career; and has contributed to the development of several clinical and marketed drug products. Ram I. Mahato is Professor and Chairman of the Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE. He was a professor at the University of Tennessee Health Science Center, Research Assistant Professor at the University of Utah, Senior Scientist at GeneMedicine, Inc., and as a postdoctoral fellow at the University of Southern California in Los Angeles, Washington University in St. Louis, and Kyoto University, Japan. He received PhD in Drug Delivery from the University of Strathclyde, Great Britain and BS from China Pharmaceutical University, Nanjing. He has published 166 peer reviewed papers, 24 book chapters, holds 3 US patents, and has edited/written nine books and eleven journal issues (Total Google Citations= 13,060 and h-Index =67). He is an Associate Editor of the Journal of Neuroimmune Pharmacology, was a Feature Editor of the Pharmaceutical Research (2006-2013). He is a CRS and AAPS Fellow. He is applying sound principles in pharmaceutical sciences in the context of the latest advances in life and material sciences to solve challenging drug delivery problems in therapeutics. His areas of research include delivery and targeting of small molecules, miRNA and genes using novel polymeric and lipid carriers for treating cancer, liver fibrosis and diabetes.