Handbook of Pediatric Epilepsy Case Studies, Second Edition

Research in the field of epilepsy will continue at a rapid pace, with the ultimate hope of curing many intractable epilepsy syndromes. Fully updated, this new edition is organized chronologically, from neonate through adolescence, and the handbook is the culmination of a group effort involving leading physicians and researchers whose contributions constitute a concise and practical reference for health professionals in training. Here the contributors review the recent flood of new information on the pathophysiology, genetics, and treatment of the various epilepsy syndromes, and the volume is distilled into an easy-to-use guide. Fully updated text reviewing the latest research on the pathophysiology, genetics, and treatment of the various epilepsy syndromes. Thorough descriptions of the different syndromes commonly encountered in clinical practice across the pediatric range. Extensive resource section provided. Contributors describe why they chose each particular case, what they learned, and how it changed their practice. The book includes the most recent classification and nomenclature published by the International League Against Epilepsy.

Section I: The Basics Chapter 1 A Pediatric Epilepsy Primer James W. Owens, MD, PhD Chapter 2 Epilepsy Genetics Primer Kimberly Wiltrout, MD and Annapurna Poduri, MD, MPH Chapter 3 Developmental Pharmacokinetics: Principles and Practice Melissa Barker-Haliski, PhD Chapter 4 Dietary Therapies for Epilepsy Eric H. Kossoff, MD Chapter 5 Vagus Nerve Stimulation Therapy James W. Wheless, MD, Nitish Chourasia, M.D and Andrew J. Gienapp, B.A. Chapter 6 Neuromodulation Devices: Responsive Neurostimulation and Deep Brain Stimulation Shifteh S. Sattar, MD Chapter 7 Epilepsy Surgery in Children Ann Hyslop, MD Chapter 8 Status Epilepticus Sonali Sen, MD and James J. Riviello, Jr, MD Chapter 9 Focal Cortical Dysplasia Harvey B. Sarnat, MD, MS, FRCPC Chapter 10 Malformations of Cortical Development Marilisa M. Guerreiro, MD, PhD and Maria Augusta Montenegro, MD, PhD Section II: The Neonate Chapter 11 Self-Limited Neonatal Epilepsy Syndromes Maria Augusta Montenegro, MD, PhD Chapter 12 Self-Limited (Familial) Infantile Epilepsy Heather Pekeles, MD and Kenneth A. Myers, MD PhD Chapter 13 Early Myoclonic Encephalopathy (Ohtahara Syndrome) Reega Purohit, MD and Linda Laux, MD Chapter 14 Early Myoclonic Encephalopathy Juan Ignacio Appendino, MD and Juan Pablo Appendino, MD Chapter 15 Hypoxic-Ischemic Encephalopathy (Neonatal Seizures) Jeffrey J. Gold, MD, PhD Chapter 16 Epilepsy of Infancy with Migrating Focal Seizures Daneille DeCampo, MD and Eric Marsh MD, PhD Section III: The Infant Chapter 17 Febrile Seizures Morris H. Scantlebury, MD Chapter 18 Genetic Epilepsy with Febrile Seizures Plus (GEFS+) Michaela Castello, MD, PhD and Aliya Frederick, MD, PhD Chapter 19 Myoclonic Epilepsy of Infancy Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr., MD Chapter 20 Dravet Syndrome Douglas R. Nordli, III, MD and Douglas R. Nordli, Jr, MD Chapter 21 Glucose Transporter-1 Deficiency Syndrome Joerg Klepper, MD Chapter 22 Infantile Epileptic Spasms Syndrome Shaun A. Hussain, MD, MS Chapter 23 Gelastic Seizures Samiya Ahmad, MD and Yu-tze Ng, MD, FRACP Chapter 24 Intractable Epilepsy after Herpes Simplex Encephalitis Daniel A. Freedman, DO and Dave F. Clarke, MD Chapter 25 Refractory Status Epilepticus Sonali Sen, MD and James J. Riviello, Jr, MD Chapter 26 Primary Mitochondrial Epilepsies Russell P. Saneto, DO, PhD Chapter 27 Tuberous Sclerosis Complex Aimee F. Luat, MD and Harry T. Chugani, MD Chapter 28 Sturge–Weber Syndrome Sabrina Tavella-Burka, DO and Ajay Gupta, MD Section IV: The Child Chapter 29 Self-Limited Epilepsy with Centrotemporal Spikes (Benign Rolandic Epilepsy) Olivia Kim-McManus, MD Chapter 30 Self-Limited Epilepsy with Autonomic Seizures (Panayiotopoulos Syndrome) Korwyn Williams, MD, PhD Chapter 31 Childhood Occipital Visual Epilepsy Maria Augusta Montenegro, MD, PhD Chapter 32 Photosensitive Occipital Lobe Epilepsy Maria Augusta Montenegro, MD, PhD Chapter 33 Childhood Absence Epilepsy Stephane Auvin, MD, PhD, FAES Chapter 34 Epilepsy with Myoclonic Absence Anita M. Devlin, MBBS, MD Chapter 35 Lennox–Gastaut Syndrome Jong M. Rho, MD Chapter 36 Epilepsy with Myoclonic-Atonic Seizures (Doose Syndrome) A.G. Christina Bergqvist, MD Chapter 37 Landau–Kleffner Syndrome Frank M. C. Besag, FRCP, FRCPsych, FRCPCH Chapter 38 Developmental/Epileptic Encephalopathy with Spike-and-Wave Activation in Sleep (D/EE-SWAS) Kevin Chapman, MD Chapter 39 Epilepsy with Eyelid Myoclonia (Jeavons Syndrome) Ifrah Zawar MD and Elia Pestana Knight MD, FAES, FACNS Chapter 40 Anti-NMDA Receptor Encephalitis Jennifer Yang, MD and Jennifer Graves, MD, PhD, MAS Chapter 41 Nonconvulsive Status Epilepticus Sonali Sen, MD and James J. Riviello, Jr, MD Chapter 42 Febrile Infection-Related Epilepsy Syndrome (FIRES) Rima Nabbout, MD, PhD and Sara Matricardi, MD, PhD Chapter 43 New-Onset Refractory Status Epilepticus (NORSE) Steven Yang, DO and Jerry Shih, MD Chapter 44 Low-Grade Developmental and Epilepsy Associated Brain Tumors Christie Becu, MD and Angus Wilfong, MD Chapter 45 Rasmussen's Encephalitis Maria Augusta Montenegro, MD, PhD Section V: The Adolescent Chapter 46 Juvenile Myoclonic Epilepsy Cornelia Drees, MD Chapter 47 Epilepsy with Generalized Tonic-Clonic Seizures Alone Kaitlin C. James and Jesus Eric Pina-Garza, MD Chapter 48 Juvenile Absence Epilepsy Maria Augusta Montenegro, MD, PhD Chapter 49 New-Onset Seizure in an Adolescent Female Mary L. Zupanc, MD Chapter 50 Temporal Lobe Epilepsy June Yoshii-Contreras, MD Chapter 51 Unverricht–Lundborg Disease Mayank Verma, MD, PhD, Danielle M. Andrade, MD and Berge A. Minassian, MD, CM, FRCP(C) Chapter 52 Reflex Seizures Maria Augusta Montenegro Chapter 53 Sleep-Related Hypermotor Epilepsy Kevin Chapman, MD Chapter 54 Psychogenic Nonepileptic Seizures Guillermo Delgado-García, MD,MSc and Colin B. Josephson, MD, MSc, MSc, FRCP(C), CSCN (EEG)

Maria Augusta Montenegro is a pediatric neurologist and epileptologist currently working at Rady Children's Hospital / University of California San Diego School of Medicine. Her clinical expertise is in pediatric epilepsy, with an emphasis on epileptic encephalopathy and EEG. Dr. Montenegro completed medical school, residency, and Ph.D. at the University of Campinas (Brazil) and a post-doctorate research fellowship at Columbia University (NY). Prior to her current position, Dr. Montenegro held an academic faculty appointment at the University of Campinas (Brazil) where she was the head of Pediatric Neurology. Dr. Jong M. Rho is a Professor of Neurosciences, Pediatrics and Pharmacology at the University of California San Diego, and Division Chief of Pediatric Neurology at the Rady Children’s Hospital San Diego. He received a bachelor’s degree in molecular biophysics and biochemistry at Yale University, and a M.D. from the University of Cincinnati. Dr. Rho has held prior faculty appointments at the University of Washington (Seattle), the University of California at Irvine, the Barrow Neurological Institute (Phoenix), and most recently, the University of Calgary. Dr. Rho's main research interests are the mechanisms underlying the anti-seizure and neuroprotective effects of metabolism-based treatments such as the ketogenic diet. His research activities have been sponsored by research grants from the U.S. National Institutes of Health, Canadian Institutes of Health Research, and other public and private sector sources.