Brain and Spinal Tumors of Childhood

This second edition comes at a time of a paradigm shift in understanding of the molecular pathology and neuroscience of brain and spinal tumors of childhood and their mechanisms of growth within the developing brain. Excellent collaborative translational networks of researchers are starting to drive change in clinical practise through the need to test many ideas in trials and scientific initiatives. This text reflects the growing concern to understand the impact of the tumour and its treatment upon the full functioning of the child’s developing brain and to integrate the judgments of the risks of acquiring brain damage with the risk of death and the consequences for the quality of life for those who survive. Information on the principles of treatment has been thoroughly updated. A chapter also records the extraordinary work done by advocates. All medical and allied professionals involved in any aspect of the clinical care of these patients will find this book an invaluable resource.

List of Contributors 1. Introduction David A. Walker, Giorgio Perilongo, Roger E. Taylor, and Ian F. Pollack 2. Epidemiology of Childhood Brain Tumors Richard J. McNally and Paul Graham Fisher 3. Clinical Presentation and Associated Syndromes of Brain Tumor David Walker, JoFen Liu, and Dhurgsharna Shanmugavadivel 4. Pediatric Central Nervous System Tumors as Phenotypic Manifestation of Cancer Predisposition Syndromes Giorgio Perilongo, Irene Toldo, and Stefano Sartori 5. Anatomical and Biological Imaging of Pediatric Brain Tumor Rob A. Dineen, Shivaram Avula, Andrew C. Peet, Giovanni Morana, and Monika Warmuth- Metz 6. Neurosurgical Techniques and Strategies Jonathan E. Martin, Ian F. Pollack, and Robert F. Keating 7. Radiotherapy for Pediatric Central Nervous System Tumors – Techniques and Strategies Nicola Thorp 8. Physical and Cognitive Rehabilitation for Children with Brain and Spinal Tumors Alexandra M. Gaynor, Helen Hartley, and Stephen A. Sands 9. Drug Delivery Gudrun Fleischhack, Martin Garnett, and Kévin Beccaria 10. Low- grade Glioma Presenting in the Optic Pathways and Hypothalamus (NF1. and Sporadic) Peter M.K. de Blank, Ian Simmons, Astrid Sehested, and Michael J. Fisher 11. Low- grade Glioma: Principles of Diagnosis and Drug Treatment Pablo Hernáiz Driever, Olaf Witt, Astrid Gnekow, Daniela Kandels, and Mark Kieran 12. High- grade Glioma Donald C. Macarthur, Christof M. Kramm, and Matthias A. Karajannis 13. Diff use Intrinsic Pontine Glioma Katherine E. Warren, Carolyn R. Freeman, and Dannis G. van Vuurden 14. Embryonal Tumors Simon Bailey and Jeff Michalski 15. Ependymoma in Childhood and Adolescence Richard Grundy and Eric Bouffet 16. Germ Cell Tumors of the Central Nervous System Matthew J. Murray, Ute Bartels, and James C. Nicholson 17. Atypical Teratoid / Rhabdoid Tumors – AT/ RT Michael C. Frühwald, Jaclyn A. Biegel, and Susan N. Chi 18. Craniopharyngioma Hermann L. Müller, Claire Alapetite, and Jeffrey Wisoff 19. Choroid Plexus Tumors and Meningiomas Kenneth K. Wong, Elwira Szychot, Jennifer A. Cotter, and Mark Krieger 20. Pediatric Spinal Tumors Rajiv R. Iyer, Nir Shimony, Mohammad Hassan A. Noureldine, Eric Bouffet, and George I. Jallo 21. Late Effects of Treatment for Childhood Brain and Spinal Tumors Ralph Salloum, Katherine Baum, Melissa Gerstle, Helen Spoudeas, and Susan R. Rose 22. The Power of Patient Advocacy in Pediatric Neuro-oncology Kathy Oliver, Susan Awrey, Mark Brougham, Gloria Garcia Castellvi, Anita Granero, Rakesh Jalali, Sacha Langton-Gilks,Yuko Moue, Kathy Riley, Bonita Suckling, Hisato Tagawa, and Raees Tonse Index

David A. Walker is Professor Paediatric Oncology, School of Medicine, University of Nottingham, Nottingham, UKGiorgio Perilongo is Director, Department of Woman’s and Child’s Health, Division of Pediatrics, University of Padua, Padua, ItalyRoger E. Taylor isProfessor of Clinical Oncology, College of Medicine, Swansea University; Honorary Consultant Clinical Oncologist, South West Wales Cancer Centre, Singleton Hospital, Swansea, UKIan F. Pollack is Chief, Pediatric Neurosurgery, Children's Hospital of Pittsburgh, Leland Albright Distinguished Professor of Neurological Surgery, Vice Chairman for Academic Affairs, Department of Neurological Surgery, Co-Director, UPCI Brain Tumor Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA