Wilms’ Tumor

This book covers all aspects of Wilms’ tumor, the second most typical solid tumor in children. Its potential for complete cure underscores correct management of this tumor. To achieve this goal, the book aims to provide all necessary details for practicing Pediatric surgeons, Oncologists, Pediatricians, Urologists, and Medical students. Topics ranging from epidemiology, etiology, pathology, clinical features, diagnostic methods, surgery, chemotherapy, radiotherapy to cutting-edge inventions are described in great detail.

The History of Renal Tumors in Children.- Epidemiology.- Genetics and Molecular Biology.- Tumor Microenvironment and Inflammatory Markers.- Syndromic Wilms’ Tumor.- Familial Non-Syndromic Wilms’ Tumor.- Pathology.- Clinical Presentation.- Laboratory Workup.- Imaging Studies.- Diagnostic Biopsy.- General Surgical Guidelines.- Nephron-Sparing Surgery.- Lymph Node Sampling.- Minimally Invasive Surgery.- Bench Surgery and Auto-Transplantation.- Anesthetic concerns.- Staging.- Systemic Chemotherapy.- Radiotherapy.- Novel Tumor Directed Interventions.- Wilms’ tumor in resource challenged nations.- Management of Resected Wilms’ Tumor with Unknown Staging Status.- Bilateral Wilms’ Tumor.- Wilms’ Tumor in Horseshoe Kidney and Solitary Kidney.- Very large tumors not responding to chemotherapy/locally infiltrating tumors.- Intravascular extension and tumor thrombosis.- Ureteral Extension.- Ruptured tumors.- Metastatic Wilms’ tumor.- Recurrent/ relapsed Wilms’ tumor.- Wilms’ Tumor in Less than 6-month-old Infants.- Wilms’ tumor in adults.- Nephrogenic rests and Nephroblastomatosis.- Extrarenal Wilms’ Tumor.- Complications of treatment.- Post-therapy surveillance of Wilms’ tumor survivors.- Prognosis and Outcomes.- Non-Wilms’ renal tumors.

Dr. Yogesh Kumar Sarin (MBBS, MS, DNB, MCh, MBA, FAIS, FICS, FIMSA, FAMS, FIAP, FNNF) is certified in General Surgery, Pediatric Surgery, and Health Care Administration (FMS, DU) and trained in Traumatology (Australia), Pediatric Laparoscopic Surgery (UK), and Pediatric Surgical Oncology (USA). Director Professor and Head of Department of Pediatric Surgery at 105-year-old Lady Hardinge Medical College, New Delhi. He has over 300 publications in national and international scientific journals with ~1300 citations, many chapters in textbooks, and has participated in/ supervised 43 research projects/ thesis. He had been editor-in-chief of an e-journal ‘Journal of Neonatal Surgery’ (2012-19); he is Emeritus Editor-in-Chief now. Member of editorial boards of two dozen more scientific journals. He is President of the Indian Association of Pediatric Surgeons. Government and non-governmental organizations have awarded him the Delhi State Award for Doctors (2012). Besides being an accomplished academician and astute administrator, he is a skilled pediatric surgeon.