Tropical Diseases From Molecule to Bedside

Tropical Diseases: From Molecule to Bedside covers a wide range of topics that reflect perspectives of northern and southern hemispheres. Fittingly, it defines tropical diseases in a broader-than-usual manner. The book discusses traditional tropical medicine topics of infectious diseases and nutritional deficiencies. These diseases are common in the tropics, although some are associated more with poverty than with tropical living conditions. It also deals with genetic diseases and genomic issues that are truly associated with living in the tropics, e.g. the thalassemias. The book begins with several papers describing the vast human genetic diversity of Southeast Asia and its relationship to several genetic disorders. These papers illustrate the future direction of genomic activities in relation to disease susceptibility and resistance. The next sections deal with malaria and four specific viral and bacterial diseases of the tropics: hepatitis B and C, tuberculosis, and leprosy, followed by a section on general bacterial infection. Two papers on nutrition complete the volume.

Genome and Disease.- Human Genome Diversity and Disease on the Island Southeast Asia.- Mitochondrial Genome and Susceptibility to Diabetes Mellitus.- Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia.- Alpha Thalassemia in Indonesia: Phenotypes and Molecular Defects.- Pathophysiology and Treatment of Iron Overload in Thalassemia Patients in Tropical Countries.- Malaria.- Maria on Islands.- Plasmodium falciparum.- Molecular Basis of Antimalarial Drug Resistance in Indonesia.- Unique properties of respiratory chain in Plasmodium falciparum mitochondria.- Performance of rapid malaria Pf antigen test for the diagnosis of malaria and false-reactivity with autoantibodies.- Phenotypic Switching and var Gene Transcription in Plasmodium falciparum.- Hepatitis B.- Hepatitis B Virus Molecular Diversity in Indonesia.- Transmission Profile of Hepatitis B Virus Infection in the Batam Region, Indonesia.- The Efficacy of a Two-Dose Hepatitis B Vaccination Scheme.- New Options in the Treatment of Chronic Hepatitis.- Hepatitis C.- Prevalence of Hepatitis C Virus Infection among Haemodialysis Patients in West Java, Indonesia.- Molecular Diversity of Hepatitis C Virus in the Batam Region.- New Treatment Options for Chronic Hepatitis C.- Tuberculosis.- pro-Inflammatory Cytokine Response in Acute Infection.- Innate Immunity to Mycobacterium tuberculosis.- Interferon-? production in response to M. Tuberculosis antigens in TB patients in Indonesia.- Immune Reactivation and Paradoxical Worsening in an HIV-Infected Tuberculosis Patient.- Leprosy.- Epidemiology of Leprosy.- Human Deficiencies in Type-1 Cytokine Receptors Reveal the Essential Role of Type-1 Cytokines in Immunity to Intracellular Bacteria.- Elimination of Leprosy and its Consequences forResearch.- General Bacterial Infections.- Antibiotic Resistance: the Pandemic.- Interference of Cryptococcus neoformanswith Human Neutrophil Migration.- Tips and Tricks from Staphylococcus aureus.- A Case of Familial Meningococcal Disease Due to Deficiency in Mannose-Binding Lectin (MBL).- Nutrition.- Micronutrient Deficiency and Supplementation in Indonesian Infants.- Micronutrient Deficiency and Supplementation in Indonesian Infants.