This book describes recent advances in translational research in breast cancer and presents emerging applications of this research that promise to have meaningful impacts on diagnosis and treatment. It introduces ideas and materials derived from the clinic that have been brought to "the bench" for basic research, as well as findings that have been applied back to "the bedside". Detailed attention is devoted to breast cancer biology and cell signaling pathways and to cancer stem cell and tumor heterogeneity in breast cancer. Various patient-derived research models are discussed, and a further focus is the role of biomarkers in precision medicine for breast cancer patients. Next-generation clinical research receives detailed attention, addressing the increasingly important role of big data in breast cancer research and a wide range of other emerging developments. An entire section is also devoted to the management of women with high-risk breast cancer. Translational Research in Breast Cancer will help clinicians and scientists to optimize their collaboration in order to achieve the common goal of conquering breast cancer.
Part I. Introduction.- Chapter 1. Translational Research in Surgical Oncology: Introduction and My Own Experience as a Surgeon-Scientist.- Part II. Breast Cancer Biology and Cell Signaling Pathways.- Chapter 2. Phospholipase Signaling in Breast Cancer.- Chapter 3. HER2 Signaling in Breast Cancer.- Chapter 4. Ras Signaling in Breast Cancer.- Chapter 5. Epigenetic Regulation in Breast Cancer.- Chapter 6. Role of tRNAs in Breast Cancer Regulation.- Chapter 7. Fusion Genes in Breast Cancer.- Chapter 8. DNA Damage Repair Inhibitor for Breast Cancer Treatment.- Part III. Cancer Stem Cell and Tumor Heterogeneity in Breast Cancer.- Chapter 9. Breast Cancer Metastasis.- Chapter 10. Single Cell Genomics for Tumor Heterogeneity.- Chapter 11. Advances in Tumor Sampling and Sequencing in Breast Cancer and their Application in Precision Diagnostics and Therapeutics.- Chapter 12. Cancer Stem Cell in Immune Microenvironment.- Chapter 13. Theranostics for Breast Cancer Stem Cells.- Chapter 14. Patient-Derived Xenograft Models in Breast Cancer Research.- Part IV Biomarkers for Precision Medicine in Breast Cancer Patients.- Chapter 15. Proteomic Interrogation in Cancer Biomarker.- Chapter 16. Next-Generation Sequencing-Based Biomarkers in Breast Cancer.- Chapter 17. Liquid Biopsy in Breast Cancer: Circulating Tumor Cells and Circulating Tumor DNA.- Chapter 18. Current Biomarkers for Precision Medicine in Breast Cancer.- Chapter 19. The Potential Predictors in Chemotherapy Sensitivity.- Chapter 20. Hormone Resistance.- Part V. Managing High Risk Women.- Chapter 21. High-Risk Population Based on BC Risk Factors.- Chapter 22. Breast Cancer-Related Low Penetrance Genes.- Chapter 23. Rare Coding Variants Associated with Breast Cancer.- Chapter 24. Multigene Panel Testing for Hereditary Cancer and Genetic Counseling.- Chapter 25. BRCA and Breast Cancer-Related High-Penetrance Genes.- Part VI. Next Generation Clinical Research.- Chapter 26. Clinical Databases for Breast Cancer Research.- Chapter 27. Care for Breast Cancer Survivors.- Chapter 28. Considerations in Oncoplastic Surgery.- Chapter 29. Diet Before and After Breast Cancer.- Chapter 30. Current Trends in and Indications for Endoscopy-Assisted Breast Surgery for Breast Cancer.- Chapter 31. Minimal Invasive and Individualizing Management of the Axillary Nodes.- Chapter 32. Malignant Phyllodes of Breast.- Chapter 33. Next-Generation Clinical Trials and Research with Successful Collaborations.- Part VII. Epilogue.- Chapter 34. Transformation of the Patient and Society: A Patient Survivors’ Group and Breast Cancer Awareness Campaign.
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