Toxicology of the Gastrointestinal Tract

This book replaces Intestinal Toxicology, one of the original books in the Target Organ series. It provides a complete, multidimensional overview of the entire gastrointestinal system involved in the toxicity of exogenous agents. The book describes normal structures and functions, regulatory mechanisms of control, and the role of absorption and metabolism in the systemic toxicity of toxic agents. It includes detailed treatment of the mechanisms of action of substances on the GI tract and how such effects can adversely affect the functioning of other systems in the body. The book also covers pharmacology, and histopathology, as well as complications and susceptibilities arising from specific disease states.

Toxicology of the Gastrointestinal Tract focuses on the specifics of the mechanisms and adverse effects of xenobiotic agents and pharmaceuticals on the structure and function of the GI tract. The book focuses on a number of specific areas of intestinal research. Beginning with the well-recognized and major functions of nutrient absorption and its role as a protective barrier, the text elaborates on the expanding body of knowledge that relates to the intestines as a major metabolic and immunologic organ involved in the synthesis and degradation of both natural and foreign substances. It includes an overview of the function and dysfunction of the human absorptive process and the effects of microbial flora on these processes, as well as specific classes of toxicants that target the GI tract. The international panel of contributors presents a critical appraisal of the interactions of chemicals and drugs with the gastrointestinal system and the experimental methods and regions of research on which to focus future efforts.

Providing a complete and multidisciplinary overview of the gastrointestinal system both in health and as it is involved in the toxicity of exogenous agents, Toxicology of the Gastrointestinal Tract brings together the current and growing knowledge of this critical organ system in a single volume.

Introduction: The Gastrointestinal Tract as Barrier and as Absorptive and Metabolic Organ, Methods for Analysis of Gastrointestinal Function, Safety Pharmacology and the GI Tract, Gastrointestinal Tract Development and Its Importance in Toxicology, Gastrointestinal Tract as Major Route of Pharmaceutical Administration, Gastrointestinal Function and Toxicology in Canines, Absorption of Macromolecules by Mammalian Intestinal Epithelium, Peyer's Patch Epithelium: An Imperfect Barrier, Alteration of Intestinal Function by Xenobiotic Exposure: Animal Models, Intestinal Absorption and Metabolism of Xenobiotics in Laboratory Animals, Normal and Abnormal Intestinal Absorption by Humans, Intestinal Absorption and Metabolism of Xenobiotics in Humans, Index