This book is the last in a series of three covering all aspects of tissue banking, donation, processing and transplantation. The first book, Tissue and Cell Donation: An Essential Guide published in April 2009 and the second book, Tissue and Cell Processing, Fehily is being developed in parallel. This new book, Tissue and Cell Transplantation, explores the clinical application of human tissues and cells for transplantation and implantation programmes around the world. It records the background to and the current state-of-the art of tissue and cell use and the changing scenarios that face the field in the near future, with the application of further technological innovation and ever-increasing national and international regulation. The collection of authors is unique, multidisciplinary, and includes clinicians, biologists and regulators who are international experts in their fields. The book is aimed at all those involved in tissue and cell clinical users of human tissues and cells and constitutes a comprehensive learning tool to comply with regulatory requirements. This book is an invaluable source of clinical information on the field to regulators, tissue and cell bankers. The scope is broad, covering all the traditionally transplanted tissues, haematopoietic stem cells, other transplanted cells and extensively manipulated (advanced therapy) and moving to complex tissue grafting and the assisted reproduction fields. Tissue and Cell Transplantation addresses the clinical principles of tissue transplantation in a generic way, with a focus on the potential for disease transmission, ways to improve safety through traceability and vigilance and surveillance, together with the role of the clinician in these safety aspects. The first part of the book takes the reader through the non-surgical risks of using allografts. The book then moves on to focus on tissue- or cell-specific issues relating to transplantation of the individual types of tissue or cells. These chapters are written to a standard template addressing issues in the past, present and future. The style of the book is consistent with others in the series and includes cases studies in text boxes and lists of learning points. Case studies, in the context of clinical use, consist of a variety of clinical issues which may illustrate such diverse factors as choosing the appropriate type of graft or where alternative therapies could be used, or where graft use improved or saved life. Sample transplantation protocols or preparation for transplantation, or examples where surgery or transplantation was not successful, are all candidates for case studies. Tissue banking and transplantation has now become a core part of the workload of transfusionists and haematologists. This series of three books covers all one needs to know about tissue banking, from donor selection and donation, to processing and transplantation.
