Thermoregulation Part I From Basic Neuroscience to Clinical Neurology

Thermoregulation, Part I: From Basic Neuroscience to Clinical Neurology, Volume 154, not only reviews how body temperature regulation changes in neurological diseases, but also how this aspect affects the course and outcomes of each disease. Other sections of the volume review three therapeutic approaches that are aimed at manipulating body temperature, including induced hypothermia, induced hyperthermia and antipyretic therapy. The book is comprised of nine sections across two volumes, five dealing with the basic aspects of body temperature regulation and four dealing with the clinical aspects. Basic sections cover the Thermoregulation system, Thermoreceptors, Thermoeffectors, Neural pathways, and Thermoregulation as a homeostatic function.

In addition, the book covers the physiology and neuroanatomy of the thermoregulation system and provides descriptions of how the regulation of body temperature intervenes with other physiological functions (such as sleep, osmoregulation, and immunity), stress, exercise and aging. Basic sections serve as an introduction to the four clinical sections: Body Temperature, Clinical Significance, Abnormal Body Temperature, Thermoregulation in Neurological Disease and Therapeutic Interventions.

SECTION I. THERMOREGULATION SYSTEM 1. The thermoregulation system and how it works

SECTION II. THERMORECEPTORS 2. Peripheral thermoreceptors in innocuous temperature detection 3. Molecular basis of peripheral innocuous cold sensitivity 4. Molecular basis of peripheral innocuous warmth sensitivity 5. Peripheral and central determinants of skin wetness sensing in humans 6. Nociceptors. Thermal allodynia and thermal pain 7. Central thermoreceptors 8. Molecular Basis of Central Thermosensation

SECTION III. THERMOEFFECTORS 9. Brown adipose tissue as a heat-production thermoeffector 10. Shivering and nonshivering thermogenesis in skeletal muscles 11. Skin vasoconstriction as a heat-conservation thermoeffector 12. Cutaneous active vasodilation as a heat-loss thermoeffector 13. Sweating as a heat-loss thermoeffector 14. Panting as a heat-loss thermoeffector 15. Thermal comfort

SECTION IV. NEURAL PATHWAYS 16. Afferent pathways for autonomic and shivering thermoeffectors 17. Efferent neural pathways for the control of brown adipose tissue thermogenesis and shivering 18. Efferent thermoregulatory pathways regulating cutaneous blood flow and sweating 19. Central neural substrates involved in temperature discrimination, thermal pain, thermal comfort, and thermoregulatory behavior

SECTION V. THERMOREGULATION AS A HOMEOSTATIC FUNCTION  20. Body temperature and sleep 21. Skin Temperature, Sleep and Vigilance 22. Thermoregulation and the ultradian basic rest-activity cycle 23. Thermoregulation and age 24. Temperature and adaptive immunity 25. Interactions between body fluid homeostasis and thermoregulation in humans 26. Obesity and Thermoregulation 27. Thermoregulation and nausea 28. Neurogenesis in the thermoregulatory system

Andrej A. Romanovsky, MD, PhD, is an integrative physiologist and neuroscientist studying body temperature regulation. Originally from St. Petersburg, Russia, Dr. Romanovsky was granted his MD with Distinction by the Ivan Pavlov Medical University (St. Petersburg) in 1984. He completed his pathophysiology residency in 1986 at the Pavlov Institute of Experimental Medicine of the Russian Academy of Medical Sciences in St. Petersburg. In 1989, he received a PhD in physiology from the Institute of Physiology of the National Academy of Sciences (Minsk, Belarus). Following postdoctoral training at the University of Tennessee Medical School in Memphis (1991-1994), Dr. Romanovsky accepted the position of Associate Scientist and Director of the Thermoregulation Laboratory at the Legacy Health System in Portland, Oregon (1994-2000). Since 1999, he has been working as Professor at St. Joseph's Hospital and Medical Center in Phoenix, Arizona, where he directs his basic research laboratory (FeverLab). He also holds an Adjunct Professor appointment at the Arizona State University School of Life Sciences in Tempe, Arizona. Dr. Romanovsky has published more than 100 articles in peer-reviewed scientific journals. His research has been funded by the National Institutes of Health, the State of Arizona, and a number of pharmaceutical companies and foundations. He has served on study sections and reviewed grant applications for the National Institutes of Health, the National Science Foundation, the Medical Research Council (UK), the Canadian Institutes of Health Research, the Swedish Research Council, the Dutch Research Council, the National Research Foundation (South Africa), the National Council of Romania, the Polish National Science Center, the government of Hong Kong, and other agencies in many countries. He has served on boards of multiple journals including the American Journal of Physiology (Regulatory, Integrative and Comparative Physiology), Public Library of Science One (Academic Editor), and Acta Physiologica Hungarica (International Board), and is the founding Editor-in-Chief of the journal Temperature. He is a co-founder of Catalina Pharma, Inc.