The Tumor Stroma Biology and Therapeutics

The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—in cancer development, progression, and metastasis has revolutionized the fields of cancer biology as well as cancer therapeutics. This book provides a comprehensive overview of this rapidly-evolving field including tumor stroma biology, therapeutic targets, molecular imaging, and advanced tumor stroma in vitro models. The book will serve as a handbook for graduate students, postgraduate researchers, pharmaceutical scientists, and biomedical engineers.

1. The Tumor Stroma: Key Component of Solid Tumors Jai Prakash 2. Cancer-Associated Fibroblasts: Building Blocks of the Tumor Stroma Ahmed M. R. H. Mostafa, Alaa M. Ramadan, Arne Östman, and Jai Prakash 3. Tumor-Associated Macrophages: Biological Understanding and Therapeutic Opportunities Siavash Mansouri and Rajkumar Savai 4. Biomarkers in the Tumor Stroma and Their Clinical Relevance Barnali Deb, Rajan Datar, Sewanti Limaye, and Prashant Kumar 5. Physical Properties of the Tumor Stroma and Therapeutic Strategies Zalak Bhut, Marcel Alexander Heinrich, and Jai Prakash 6. TGF-ß Signalling in Cancer: Role and Therapeutic Targeting of the Tumour Stroma Adilson Fonseca Teixeira, Peter ten Dijke, and Hong-Jian Zhu 7. Role of Integrins in the Tumor Stroma Kunal Pednekar, Marcel Alexander Heinrich, and Jai Prakash 8. MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications Tao Lu, Leon W. M. M. Terstappen, and Jai Prakash 9. Molecular Imaging of the Tumor Stroma and Beyond F. A. Vuijk, R. Houvast, V. M. Baart, C. J. H. van de Velde, A. L. Vahrmeijer, D. E. Hilling, J. S. D. Mieog, M. Slingerland, L. F. de Geus-Oei, L. J. A. C. Hawinkels, and C. F. M Sier 10. 3D in vitro Models to Mimic the Tumor Microenvironment Marcel Alexander Heinrich, Ngoc Tien Huynh, Yu Shrike Zhang, and Jai Prakash

Jai Prakash, Professor at the University of Twente in the Netherlands, is a pharmaceutical and bioentrepreneurial scientist working in the field of engineered therapeutics against cancer and fibrosis. He is educated as a pharmacologist and obtained his PhD (with honors) from the University of Groningen, the Netherlands. Earlier, he worked as vice president at BiOrion Technologies and Assistant Professor at Karolinska Institutet, Sweden, and then joined as a tenure track professor at the University of Twente. He is also a founder and CSO of ScarTec Therapeutics and the president of BeNeLux and France local chapter for the Controlled Release Society (CRS). His research interests are in designing therapeutic technologies to disrupt the crosstalk between tumor cells and stromal cells and in developing advanced 3D in vitro models to mimic the tumor microenvironment.