The Theory Of Response-Adaptive Randomization In Clinical Trials - Hu Feifang; Rosenberger William F. | Libro John Wiley & Sons 09/2006 - HOEPLI.it


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hu feifang; rosenberger william f. - the theory of response-adaptive randomization in clinical trials

The Theory of Response-Adaptive Randomization in Clinical Trials

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Dettagli

Genere:Libro
Lingua: Inglese
Pubblicazione: 09/2006





Trama

Presents a firm mathematical basis for the use of response-adaptive randomization procedures in practice


The Theory of Response-Adaptive Randomization in Clinical Trials is the result of the authors' ten-year collaboration as well as their collaborations with other researchers in investigating the important questions regarding response-adaptive randomization in a rigorous mathematical framework. Response-adaptive allocation has a long history in biostatistics literature; however, largely due to the disastrous ECMO trial in the early 1980s, there is a general reluctance to use these procedures.

This timely book represents a mathematically rigorous subdiscipline of experimental design involving randomization and answers fundamental questions, including:
* How does response-adaptive randomization affect power?
* Can standard inferential tests be applied following response-adaptive randomization?
* What is the effect of delayed response?
* Which procedure is most appropriate and how can "most appropriate" be quantified?
* How can heterogeneity of the patient population be incorporated?
* Can response-adaptive randomization be performed with more than two treatments or with continuous responses?

The answers to these questions communicate a thorough understanding of the asymptotic properties of each procedure discussed, including asymptotic normality, consistency, and asymptotic variance of the induced allocation. Topical coverage includes:
* The relationship between power and response-adaptive randomization
* The general result for determining asymptotically best procedures
* Procedures based on urn models
* Procedures based on sequential estimation
* Implications for the practice of clinical trials

Useful for graduate students in mathematics, statistics, and biostatistics as well as researchers and industrial and academic biostatisticians, this book offers a rigorous treatment of the subject in order to find the optimal procedure to use in practice.







Altre Informazioni

ISBN:

9780471653967

Condizione: Nuovo
Collana: Wiley Series in Probability and Statistics
Dimensioni: 240 x 19.15 x 156 mm Ø 514 gr
Formato: Copertina rigida
Pagine Arabe: 232






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