Published upon the opening of the Wellcome Collection, the Wellcome Trust's new public venue in London, this book examines the history of our understanding of the human heart. The book first explores the symbolic significance of the heart in ancient Egypt, China, India, and Greece; its role in Aztec ceremony; and its place in the medieval world. It then considers the centrality of the heart in Christianity and other religions and the literary and artistic views of the heart as the seat of the soul and emotions. The growth of anatomical knowledge of the heart and its treatment through developing technology is fundamental to the volume.