The Fine Blueprint of Integrating Immunotherapy and Radiotherapy From Molecular Mechanisms to Clinical Strategies

This book provides a comprehensive overview of the principles and applications of immunotherapy and radiotherapy in the treatment of cancer. It covers the basic concepts of immunotherapy, immunology, radiation physics, radiobiology, and tumor biology, as well as their clinical aspects, such as patient selection, treatment planning, delivery techniques, toxicity management, outcome evaluation, and neoadjuvant approaches. The book also discusses the current challenges and future directions in the field, such as combining immunotherapy and radiotherapy, optimizing the timing and sequencing of treatments, developing novel biomarkers and predictive models, and implementing personalized and adaptive approaches. The book is intended for oncologists, radiation oncologists, medical physicists, radiation therapists, immunologists, researchers, students, and anyone interested in learning more about this rapidly evolving area of cancer therapy.

Part I. Introduction.- Chapter 1. Cancer Immunology and Immunotherapy.- Chapter 2. Basis of Radiobiology and Its Relevance to Immunoradiotherapy.- Chapter 3. Advanced Nanobiomaterials-mediated Radio-immunotherapy in Malignant Cancer.- Part II. The Immunoradiotherapy in Malignant Cancer.- Chapter 4. The Immunoradiotherapy in HNSCC.- Chapter 5. Progress of Radiotherapy Combined with Immunotherapy for Non-small Cell Lung Cancer.- Chapter 6. The Immunoradiotherapy in Nasopharyngeal Carcinoma.- Chapter 7. The Combination of Immunotherapy and Radiotherapy in Pancreatic Ductal Adenocarcinoma.- Chapter 8. The Immunoradiotherapy in Cervical Cancer.- Part III. The Future of Immunoradiotherapy.- Chapter 9. Pioneering Immunotherapy Agents and their Synergy with Radiotherapy.- Chapter 10. Dual Facets of Ionizing Radiation in Cancer Therapy: Immunomodulation and Immunosuppression.- Chapter 11. Precision Medicine in Immunoradiotherapy.

Lin-Lin Bu is an associate professor and associate chief physician of Wuhan University Stomatological Hospital. He obtained his doctoral degrees at Wuhan University Stomatological Hospital, under the mentorship of professors Wen-Feng Zhang and Zhi-Jun Sun. He later conducted postdoctoral research with professor Zhen Gu’s team at the University of North Carolina at Chapel Hill and the University of California, Los Angeles. He was selected as a young medical backbone talent in Wuhan and a top young medical talent (first level) in Hubei Province. Dr. Bu has received the “Qiu Weiliu Oral and Maxillofacial Surgery Hope Award” and the “Zhu Yubi Medical Award” from Wuhan University. His research focuses on oral and maxillofacial tumor resection and reconstruction (where he introduced the “Less Is More” concept); oral cancer lymph node metastasis (where he proposed the “PUMP+” principle); the development of biomimetic drug delivery platforms combining medicine and engineering; and innovative teaching methods in head and neck surgery (where he proposed the “PRI-E” teaching model). He has authored 66 first- and corresponding-author papers in prestigious SCI journals. Dr. Bu has also been invited to serve as a guest editor for Seminars in Cancer Biology, Burns and Traum, Journal of Nanobiotechnology and BMC Medical Education.

Qiuji Wu obtained his Ph.D. degree in Oncology from Gustave Roussy Cancer Institute. He is an associate professor and master’s supervisor at Wuhan University, and a deputy chief physician at Zhongnan Hospital of Wuhan University. He currently serves as the deputy director and director of Teaching for the Department of Radiation and Medical Oncology (Gynecological Oncology). Dr. Wu’s clinical activities primarily focus on the precision radiotherapy and immunotherapy of malignant tumors. He has been selected for the “Global Clinical Scholars Research Training Program (GCSRT)” at Harvard Medical School, the “International Medical Education Faculty Training Program (IMEP)” at the University of Chicago, and the first “Young Clinician Scientist Training Program” at the National Cancer Center of China. His research interests include the role and mechanisms of radiation on cancer immunity and its application in cancer treatment, as well as the mechanisms of radioresistance of cancers. Dr. Wu has led multiple research projects and published more than 40 scientific papers in journals such as Cell Death and Differentiation, Journal of Nanobiotechnology,