The Developing Brain and its Connections

The Developing Brain and Its Connections describes the processes of neural development from neural induction through synaptic refinement. Each chapter explores specific mechanisms of development and describes key experiments from invertebrate and vertebrate animal models. By highlighting experimental methods and explaining how hypotheses evolve over time, readers learn essential facts while strengthening their appreciation of the scientific method. Discussions of neurodevelopmental disorders and therapeutic approaches to them bridge basic science discoveries with the clinical aspects of the field. Descriptions of recent work by student researchers and medical residents demonstrate career pathways and options for those interested in pursuing any area neural development. With this distinctive approach, easy-to-follow writing style, and clear illustrations, The Developing Brain presents an accessible approach to neural development for undergraduate students. Related TitlesLuo, L. Principles of Neurobiology, 2nd edition (ISBN 9780815346050)Simon, S. A., series ed. Frontiers in Neuroscience https://www.routledge.com/Frontiers-in-Neuroscience/book-series/CRCFRONEUSCI Feltz, A., ed. Physiology of Neurons (ISBN 978-0-8153-4600-5)

Author Biography Preface 1. An Introduction to the Field of Developmental Neurobiology 2. Neural Induction 3. Segmentation of the Anterior– Posterior Axis 4. Patterning along the Dorsal– Ventral Axis 5. Proliferation and Migration of Neurons 6. Cell Determination and Early Differentiation 7. Neurite Outgrowth, Axonal Pathfi nding, and Initial Target Selection 8. Neuronal Survival and Programmed Cell Death 9. Synaptic Formation and Reorganization Part I: The Neuromuscular Junction 10. Synaptic Formation and Reorganization Part II: Synapses in the Central Nervous System Glossary Index

Lynne M. Bianchi is Emerita Professor of Neuroscience at Oberlin College where she taught and mentored undergraduate students for over 20 years. She is currently the Director of Medical Research for the University of Pittsburgh Medical Center Hamot and Gannon University where she supports investigators interested in clinical and basic science research. In addition to her work investigating the role of nerve growth factors during embryonic development, she mentors young clinician-scientists as they develop their ideas into exciting research projects.