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This comprehensive textbook brings together global experts to deliver an in depth, evidence based guide covering the full spectrum of acquired and inherited marrow failure syndromes. It explores cutting edge advances in diagnostics including next generation sequencing , other genetic studies and the evolving progress in treatment strategies including immunosuppressive therapy, hematopoietic stem cell transplantation, and targeted agents. Special attention is given to age specific management, overlap syndromes and the increasingly recognized inherited bone marrow failure disorders. A dedicated section addresses the unique challenges faced in resource limited settings, offering strategies to improve global access to care. Designed for clinicians, researchers, and allied health professionals, this textbook serves as an essential, practical reference that bridges research and real world practice. It equips readers with the tools to improve outcomes for patients worldwide affected by bone marrow failure.
This book is open access.
Epidemiology of Acquired Bone Marrow Failure.- Pathophysiology of Acquired Bone Marrow Failure.- Role of Next Generation Sequencing in Diagnosis of Inherited and Acquired Bone Marrow Failure.- Diagnosis of Acquired Aplastic Anemia.- Acquired Overlap Bone Marrow Failure Disorders.- Supportive Care in Aplastic Anemia.- Immunosuppressive Therapy for Aplastic Anemia.- Identical Sibling Donor Transplantation.- Unrelated Donor Transplants for Acquired Aplastic Anemia.- Umbilical Cord Blood Transplantation for Patients.- Haploidentical Transplantation.- Management of Acquired Aplastic Anemia in Children.- Treatment of Elderly Patients with Aplastic Anemia.- Emerging New Therapies for Acquired Bone Marrow Failure Disorders.- Bone Marrow Failure in Paroxysmal Nocturnal Hemoglobinuria.- Managing Bone Marrow Failure in Countries with Restricted Resource.- Telomere Biology and Disease.- Fanconi Anemia.- Ribosomopathies and the Quality Control of Ribosome Assembly.- Dyskeratosis Congenita.- Amegakaryocytic Thrombocytopenia.- Severe Congenital Neutropenias and Other Rare Inherited Disorders with Marrow Failure.- Bone Marrow Failure Syndromes in Children.
Dr. Mahmoud Aljurf MD
Director of Adult Stem Cell Transplantation and Cell Therapy Program
Deputy Director of the Oncology Centre
King Faisal Specialist Hospital & Research Centre
Riyadh, Saudi Arabia
Régis Peffault de Latour
Professor of Hematology
Department of Hematology and Bone Marrow Transplant
Saint-Louis Hospital
Paris, France
Andrea Bacigalupo
Fondazione Policlinico Universitario Gem
Rome, Italy
Carlo Dufour
Chair of the Clinical and Experimental Hematology Unit
Department of Hematology
G. Gaslini Children Research Hospital
Genova, Italy


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