Templated DNA Nanotechnology Functional DNA Nanoarchitectonics

Nucleic acids have structurally evolved over billions of years to effectively store and transfer genetic information. In the 1980s, Nadrian Seeman’s idea of constructing a 3D lattice from DNA led to utilizing DNA as nanomolecular building blocks to create emergent molecular systems and nanomaterial objects. This bottom-up approach to construct nanoscale architectures with DNA marked the beginning of a new field, DNA nanotechnology, contributing significantly to the broad area of nanoscience and nanotechnology. The molecular architectonics of small "designer" molecules and short DNA sequences through complementary binding interaction engenders well-defined functional nanoarchitectures with realistic applications in areas ranging from biology to materials science and is termed "DNA nanoarchitectonics." This book discusses novel approaches adapted by leading researchers from all over the world to create functional nucleic acid molecular systems and nanoarchitectures. Individual chapters contributed by active practitioners provide fundamental and advanced knowledge emanated from their own and others’ work. Each chapter includes numerous illustrations, historical perspectives, case studies and practical examples, critical discussions, and future prospects. This book can serve as a practical handbook or as a textbook for advanced undergraduate- and graduate-level students of nanotechnology and DNA nanotechnology, supramolecular chemistry, and nanoarchitectonics and researchers working on macromolecular science, nanotechnology, chemistry, biology, and medicine, especially those with an interest in sensors, biosensors, nanoswitches and nanodevices, diagnostics, drug delivery, and therapeutics.

Multichromophore Stacks in DNA: Novel Light-Harvesting Systems Robert Hofsäß and Hans-Achim Wagenknecht DNA-Programmed Nanoscale Assemblies of Covalently Linked Functional Monomers Prolay Das and Seema Singh Functional Molecule–Templated DNA Nanoarchitectures Bappaditya Roy, Debasis Ghosh, and Thimmaiah Govindaraju Functional DNA Amphiphiles Murali Golla, Hari Veera Prasad Thelu, Shine K. Albert, Nithiyanandan Krishnan, Siriki Atchimnaidu, Devanathan Perumal, Sai Praveen Thaddi, and Reji Varghese Nucleoside Lipid–Based Soft Materials Alexandra Gaubert, Laurent Latxague, and Philippe Barthélémy Excited-State Dynamics in Chromophore-Appended Nucleic Acids Abbey M. Philip, Vinayak Bhat, and Mahesh Hariharan Templated Arrays of Multichromophores and Oligonucleotides Supported by Metal Interactions and Their Functional Relevance Mitsunobu Nakamura, Tadao Takada, and Kazushige Yamana Carbon Nanomaterial–Nucleic Acid Complexes and Their Biological Applications Ngoc Do Quyen Chau, Giacomo Reina, and Alberto Bianco Self-Assembled Functional Fullerenes and DNA Hybrid Nanomaterials for Various Applications Sandeepa K. Vittala, Sajena K. Saraswathi, and Joshy Joseph Nucleic Acid–Based Biosensors and Molecular Devices Deepti Sharma, Prasanna Kumar Athyala, and Ashwani Sharma DNA-Based Nanoswitches and Devices Bappaditya Roy, Madhu Ramesh, and Thimmaiah Govindaraju

Thimmaiah Govindaraju is professor at the Bioorganic Chemistry Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, India. He received his MSc in chemistry in 2000 from Bangalore University, India, and PhD in chemistry in 2005 from the National Chemical Laboratory and the University of Pune, India. From 2005 to 2006, he pursued his postdoctoral research at the University of Wisconsin–Madison, USA, and from 2006 to 2008 the Alexander von Humboldt fellowship at the Max Planck Institute of Molecular Physiology, Dortmund, Germany. Dr. Govindaraju has published more than 90 papers in peer-reviewed journals and several book chapters and holds more than 10 patents. Many of his laboratory inventions have been commercialized or licensed to develop bioimaging and point-of-care diagnostics. He is also cofounder of a start-up company, VNIR Biotechnologies Pvt. Ltd. He has received awards such as "India’s Young Blood" by Chemical and Engineering News, ACS, USA, and the Sir C. V. Raman Young Scientist Award by the government of Karnataka (2014). He is also secretary of the Chemical Research Society of India (CRSI) and the Indian Peptide Society (IPS). His research interests are at the interface of chemistry, biology, and (bio)materials sciences and include Alzheimer’s disease (disease amyloids), peptide chemistry, molecular probes, molecular architectonics,