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Targeting Trafficking in Drug Development

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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

Springer

Pubblicazione: 04/2018





Trama

Cellular trafficking is only recently identified as a site for therapeutic intervention. This book provides up to date information on the mechanism for exploiting this area for drug development as well as a clear understanding of the individual components of cellular trafficking. The authors are experts in their areas and the book features tables and figures that enable comparison and clear understanding.





Sommario

Preface
1. Intracellular trafficking of gonadotropin receptors in health and disease. (Ulloa-Aguirre et al)
2. Investigating internalization and intracellular trafficking of GPCRs. (Simon R. Foster and Hans Bräuner-Osborne) 
3. Pharmacological chaperones as potential therapeutic strategies for misfolded mutant vasopressin receptors. (Bernard Mouillac and Christiane Mendre)
4. Targeting of disordered proteins by small molecules in neurodegenerative diseases. (Francesca Longhena, PierFranco Spano, Arianna Bellucci
5. Pharmacoperones for misfolded gonadotropin receptors. (Claire L. Newton and Ross C. Anderson)
6. Pharmacological chaperones: Beyond conformational disorders. (Nancy J. Leidenheimer)
7. Natural (and unnatural) small molecules as pharmacological chaperones and inhibitors in cancer. Isabel Betancor, (David J. Timson, Eduardo Salido, Angel L. Pey)
8. Heritable skeletal disorders arising from defects in processing and transport of Type I procollagen from the ER: perspectives on possible therapeutic approaches. (Meritxell B. Cutrona, Niamh E. Morgan, Jeremy C. Simpson)
9. Conserved oligomeric Golgi and neuronal vesicular trafficking. (Leslie K. Climer, Rachel D. Hendrix, Vladimir V. Lupashin)
10. SLC6 transporter folding diseases and pharmacochaperoning. (Michael Freissmuth, Thomas Stockner, Sonja Sucic)
11. The molecular physiopathogenesis of islet amyloidosis. (Diti Chatterjee Bhowmick, Sanghamitra Singh, Saurabh Trikha, Aleksandar M. Jeremic)
12. Folding defects leading to primary hyperoxaluria. (Elisa Oppici, Mirco Dindo, Carolina Conter, Carla Borri Voltattorni, Barbara Cellini)
13. Potential pharmacological chaperones for cystathionine beta-synthase-deficient homocystinuria. (Tomas Majtan, Angel L. Pey, Paula Gimenez-Mascarell, Luis Alfonso Martínez-Cruz, Csaba Szabo, Victo Kosich, Jan P. Kraus)










Altre Informazioni

ISBN:

9783319741635

Condizione: Nuovo
Collana: Handbook of Experimental Pharmacology
Dimensioni: 235 x 155 mm Ø 811 gr
Formato: Copertina rigida
Illustration Notes:VIII, 425 p. 57 illus., 55 illus. in color.
Pagine Arabe: 425
Pagine Romane: viii


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