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farkas etelka (curatore); marmion celine j. (curatore) - targeted metallo-drugs
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Targeted Metallo-Drugs Design, Development, and Modes of Action

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Genere:Libro
Lingua: Inglese
Editore:

CRC Press

Pubblicazione: 05/2023
Edizione: 1° edizione





Note Editore

Volume 24, entitled Targeted Metallo-Drugs: Design, Development, and Modes of Action, of the series Metal Ions in Life Sciences (MILS), fosters inter-disciplinary research in the vibrant field of Biological Inorganic Chemistry. Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development. It covers anticancer, antimicrobial, antiviral, and other agents, such as those targeting tropical diseases and cyanide poisoning and radiometals in molecular imaging and therapy It highlights recent metallo-drug developments targeting COVID-19 It features advanced spectroscopic methods and metallomics as important tools to elucidate the modes of actions of metallo-drugs




Sommario

Chapter 1 Metal-Based Prodrugs Activated by Cancer-Specific Stimuli Martijn Dijkstra, Hemma Schueffl, Isabella Poetsch, Petra Heffeter, and Christian R. Kowol. Chapter 2 Light-Activated Drugs for Photodynamic and Photoactivated Therapy Dmytro Havrylyuk, Austin Hachey, and Edith Glazer. Chapter 3 Mitochondria as a Metallo-Drug Target for Therapeutic Purposes Andrea Erxleben. Chapter 4 Transition Metal-Based Anti-Viral Agents against SARS-CoV-2 and Other Pathogenic Viruses Maria Gil-Moles and Ingo Ott. Chapter 5 Exploiting the Chemical Diversity of Metal Compounds as a Source of Novel Anti-COVID-19 Drugs Damiano Cirri, Tiziano Marzo, Carlo Marotta, Alessandro Pratesi,, and Luigi Messori. Chapter 6 Evaluating the Potential of Novel Metal-Based Drugs for Treating Drug Resistant Bacteria Andris Evans and Kevin Kavanagh. Chapter 7 Prospective Metallo-Drugs Including Bioactive Compounds: Selection of Co-Ligands to Tune Biological Activity against Neglected Tropical Diseases Dinorah Gambino and Lucía Otero. Chapter 8 Challenges in Targeting Cyanide Poisoning: Advantages in Exploiting Metal Complexes in Its Treatment Sigridur G. Suman. Chapter 9 Advanced Microscopy Methods for Elucidating the Localization of Metal Complexes in Cancer Cells Johannes Karges and Nils Metzler-Nolte. Chapter 10 Metalloproteomics: A Powerful Technique for Metals in Medicine Tiffany Ka-Yan Ip, Ying Zhou, Hongyan Li, and Hongzhe Sun. Chapter 11 Metal-Based Nanoclusters for Biomedical Applications Edit Csapó. Chapter 12 Radiometals in Molecular Imaging and Therapy Izabela Cieszykowska, Wioletta Wojdowska, Dariusz Pawlak, and Renata Mikolajczak.




Autore

Etelka Farkas is Emeritus Professor (2016) at the Faculty of Science and Technology, Department of Inorganic and Analytical Chemistry at the University of Debrecen, Hungary. After receiving her scientific degree (D.Sc.) from the Hungarian Academy of Sciences (HAS) in 1998, she has worked as elected member in some HAS Committees, e.g., the Committee on Physical Chemistry and Inorganic Chemistry (2011–) and the Doctoral Council of Chemical Sciences (2018–2021), and she chaired the Working Commitee of Coordination Chemistry (2011–2017). From 2006 to 2019, she was also Chair of the International Relations of the Hungarian Chemical Society. Her research has been focused, first of all, on the bio-induced solution study of metal complexes with a large variety of ligands, e.g. amino acid-, peptide-, and hydroxamic acid-based ligands, and the results have been presented in ca. 180 publications. Professor Farkas was Editor of the RSC Specialist Periodical Reports (Vols. 37, 38, and 39) on Amino Acids, Peptides, and Proteins for the years 2012, 2013, and 2015. Furthermore, she was Guest Editor of the Special Issue 472 (2018) of Inorganica Chimica Acta and of the issue 206 (2020) of the Journal of Inorganic Biochemistry. She received many awards; to mention just three of them: (2005) Gold Cross of Merit of the Hungarian Republic; (2012) Albert Szent-Györgyi Award; and (2022) Academy Prize, Awarded by the HAS. Celine J. Marmion is Professor of Bioinorganic Chemistry (since 2018) and Deputy Dean for Student Engagement (2018–2024) in RCSI, University of Medicine and Health Sciences, Dublin, Ireland. Her current research focusses on the rational design and development of innovative, multi-targeted metallo-drug candidates as anticancer or antimicrobial drugs. She has a track record in commercializing her research with the patient at the heart of all that she does. In this regard, she, together with colleagues, executed a pharma license agreement on a metallo-drug technology in 2010 and, more recently, entered into an industry-funded collaboration and option agreement with another pharma in 2016. Professor Marmion has undertaken many senior leadership roles within and outside her university. She is currently an active Council member of the Society of Biological Inorganic Chemistry. She was President of the Institute of Chemistry of Ireland, the national body representing all chemists in Ireland from 2019 to 2022, the third female only to be elected as President since its establishment in 1922. She also co-founded the Irish Biological Inorganic Chemistry Society in 2017 and served as its President from 2018 to 2020. Professor Marmion is a strong and vocal advocate for young scientists. In this regard, she played a key role in the establishment of the Institute of Chemistry of Ireland Young Chemists’ Network. She is also deeply committed to nurturing excellence in the education of students. She was the recipient of national "Teaching Hero" awards in 2021 and 2016 (as nominated by students) and numerous RCSI President's Teaching Awards. Astrid Sigel has studied languages; she was an Editor of the Metal Ions in Biological Systems (MIBS) series (until Volume 44) and also of the Handbook on Toxicity of Inorganic Compounds (1988), the Handbook on Metals in Clinical and Analytical Chemistry (1994; both with H. G. Seiler and H.S.), and on the Handbook on Metalloproteins (2001; with Ivano Bertini and H.S.). She is also an Editor of the MILS series from Volume 1 on, and she co-authored more than 50 papers on topics in Bioinorganic Chemistry. Helmut Sigel is Emeritus Professor (2003) of Inorganic Chemistry at the University of Basel, Switzerland. He is a Co-editor of the series Metal Ions in Biological Systems (1973–2005; 44 volumes) as well as of the Sigels' new series Metal Ions in Life Sciences (since 2006). He also co-edited three handbooks and published over 350 articles on metal ion complexes of nucleotides, amino acids, coenzymes, and other bio-ligands. Together with Ivano Bertini, Harry B. Gray, and Bo G. Malmström, he founded (1983) the International Conferences on Biological Inorganic Chemistry (ICBICs). He lectured worldwide and was named Protagonist in Chemistry (2002) by Inorganica Chimica Acta (issue 339). Among Endowed Lectureships, appointments as Visiting Professor (e.g., Austria, China, Japan, Kuwait, UK), and further honors, he received the P. Ray Award (Indian Chemical Society, of which he is also a Honorary Fellow), the Alfred Werner Award (Swiss Chemical Society), and a Doctor of Science honoris causa degree (Kalyani University, India). He is also an Honorary Member of SBIC (Society of Biological Inorganic Chemistry). Eva Freisinger is Associate Professorof Bioinorganic Chemistry and Chemical Biology (2018) at the Department of Chemistry at the University of Zürich, Switzerland. She obtained her doctoral degree (2000) from the University of Dortmund, Germany, working with Bernhard Lippert, and spent three years as










Altre Informazioni

ISBN:

9781032223308

Condizione: Nuovo
Collana: Metal Ions in Life Sciences Series
Dimensioni: 9 x 6 in Ø 1.94 lb
Formato: Copertina rigida
Illustration Notes:53 b/w images, 43 color images, 7 tables, 15 halftones, 28 color halftones, 38 line drawings and 15 color line drawings
Pagine Arabe: 370
Pagine Romane: xx


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