Structural Biology of the Complement System

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in this emerging science. Structural Biology of the Complement System is devoted to the full exploration of structural aspects of the complement system, with special consideration of the links between molecular structure and function.Containing the work of leading authorities across the disciplines of immunology and structural biology, the book serves both as an introductory volume for newcomers to the field and as a comprehensive reference for established researchers, in particular those whose goal is the discovery of anticomplement drugs. Written in a didactic style, this volume is an appropriate resource for students in the fields of immunology and structural biology.Structural Biology of the Complement System comes with downloadable resources containing color figures, a molecular structure visualization program, and files with three-dimensional coordinates of the structures described in the book. These tools allow readers to perform tailored structural manipulation and analysis, while also serving as a starting point for further research.

The Building Blocks of the Complement System, D. Morikis and J. D. LambrisComplement Control Protein Modules in the Regulators of Complement Activation , D. C. Soares and P. N. BarlowThe Classical Pathway C1 Complex, G. J. Arlaud, C. Gaboriaud, N. M. Thielens, L. A. Gregory, J. Juanhuix, V. Rossi, and J. C. Fontecilla-CampsFactors D and B: Substrate-Inducible Serine Proteases of the Alternative Pathway of Complement Activation, Yuanyuan Xu, Karthe Ponnuraj, Sthanam V. L. Narayana, and John E. VolanakisThe Structures of Human Complement Fragments C3d and C4Ad and the Functional Insights That They Have Provided , D. E. Isenman and J. M. H. van den ElsenComplement Receptor CR2/CD21 and CR2-C3d Complexes , J. P. Hannan, G. Szakonyi, R. Asokan, X. Chen, and V. M. HolersStructure of the Anaphylatoxins C3a and C5a, D. Morikis, M. C. H. Holland, and J. D. LambrisC3b/C4b Binding Site of Complement Receptor Type 1 (CR1, CD35), M. Krych-Goldberg, P. N. Barlow, R. L. Mallin, and J. P. AtkinsonFrom Structure to Function of a Complement Regulator:Decay-Accelerating Factor (CD55), P. Lukacik, P. Roversi, R. A. G. Smith, and S. M. LeaComplement Protein C8, L. Lebioda and J. M. SodetzStructure-Function Relationships in CD59, B. P. Morgan and S. TomlinsonComplement-like Repeats in Proteins of the Complement System, K. Dolmer and P. G. W. GettinsComplement and Immunoglobulin Protein Structures by X-Ray and Neutron Solution Scattering and Analytical Ultracentrifugation, S. J. Perkins and B. FurtadoStructure, Dynamics, Activity, and Function of Compstatin and Design of More Potent Analogues ,D. Morikis and J. D. LambrisDiscovery of Potent Cyclic Antagonists of Human C5a Receptors, S. M. Taylor and D. P. Fairlie

Morikis\, Dimitrios; Lambris\, John D.