Signaling Through Cell Adhesion Molecules

The field of signal transduction research is one of the fastest growing in all of biomedical research in recent years. Signaling through cell adhesion molecules have long been of interest because of their importance in embryonic development, homeostasis, immune responses, wound healing , and malignant transformation. However, it is only recently realized that cell adhesion molecules are capable of transduce biochemical signals across the plasma membrane to regulate cellular functions.Signaling Through Cell Adhesion Molecules brings together novel and current methodology employed in studies of signaling by cell adhesion molecules as presented by leading experts whose research has shaped this nascent area of signal trandsduction research. One of the unique features of this method book is its topic-oriented format; experts with "hands-on" experience present various techniques and answers to particular biological questions. Many chapters not only contain the "recipes" on experimental protocols, but also discuss the rationale behind their development.

Protein-Protein Interactions and Early Events in Integrin Signaling The Use of Chimeric Receptors in the Study of Integrin Signaling Using Synthetic Peptides to Mimic Integrins: Probing Cytoskeletal Interactions and Signaling Pathways Use of the Yeast Two-Hybrid System for the Characterization of Integrin Signal Transduction Pathways: Identification of the Integrin-Linked Kinase, p59 Focal Adhesion Kinase and its Associated Proteins Analysis of Paxillin as a Multi-Domain Scaffolding Protein p130 in Integrin Signaling Specificity of Integrin Signaling Late Events and Biological Functions of Integrin Signaling Methods for Study of Integrin Regulation of MAP Kinase Cascades Methods for Analysis of Adhesion-Dependent Cell Cycle Progression Integrin Modulation of Mitogenic Pathways Involved in Muscle Differentiation Methods for Studying Anoikis Functional Analysis of FAK and Associated Molecules in Cell Migration Integrin Signaling in Pericellular Matrix Assembly Inside-out Signaling by Integrins Studies of Integrin Signaling Through Platelet ab Tracking of Integrin-Mediated Adhesion Using Green Fluorescent Protein and Flow Cytometry Expression Cloning of Proteins That Modify Integrin Activation Regulation of Cell Contractility by RhoA: Stress Fiber and Focal Adhesion Assembly Studies of Integrin Signaling Through Platelet General Methods for Studies of Cell Adhesion Molecule-Mediated Signaling Intra-and Intercellular Localization of Proteins in Tissue in situ Optical Microscopy Studies of (Ca2) Signaling Wnt Signaling in Xenopus Embryos

Jun-Lin Guan