Receptor - Based Drug Design

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. Explains the experimental and theoretical methods used to characterize interactions between ligands and receptors-providing the pharmacological information needed to solve treatment problems and facilitate the drug design process! Demonstrating the achievements of the receptor-based approach in therapeutics and indicating future directions, Receptor-Based Drug Design 7introduces novel computer-assisted strategies for the design of new agonists, antagonists, and inverse agonists for G-protein-coupled receptors 7shows how to assess agonist concentration-effect curve data 7discusses radioligand binding assays 7presents new in vitro multiarray assays for G-protein-coupled receptors 7explains the use of individual second messenger signaling responses in analyzing drug-receptor interactions 7examines the role of electrophysiology in finding new drugs and drug targets 7describes selectively acting b-adrenoceptor agonists and glucocorticoid steroids for asthma treatment 7outlines the rationale for using angiotensin receptor antagonists 7and more! Written by over 25 international authorities and containing nearly 1200 bibliographic citations, Receptor-Based Drug Design is a practical resource for pharmacologists, pharmacists, and pharmaceutical scientists; organic and medicinal chemists and biochemists; molecular biologists; biomedical researchers; and upper-level undergraduate and graduate students in these disciplines.

Introduction, James Black Principles and Measurement of Drug-Receptor Interactions The Characterization and Classification of Receptors, Patrick P. A. HumphreyFunctional Methods for Quantifying Agonists and Antagonists, Iain G. DougallQuantification of Receptor Interactions Using Binding Methods, Sebastian LazarenoDrug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors, T. Kendall Harden, José L. Boyer, and Robert W. DoughertyThe Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions, John G. Connolly and Charles KennedyReceptor-Based Drugs in Medicine Selective Adrenergic and Glucocorticoid Treatments for Asthma, David JackSerotonin 5-HT1B/D Receptor Agonists, Graeme R. MartinHistamine H2-Receptor Antagonists, Michael E. ParsonsAngiotensin Antagonists, Mark J. RobertsonExperimental and Emerging Drugs -Adrenoceptor Agonists and Antagonists, J. Paul Hieble and Robert R. Ruffolo, Jr.P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases, Eduardo R. Lazarowski, William C. Watt, T. Kendall Harden, and Richard C. BoucherMuscarinic Receptor Antagonists Pharmacological and Therapeutic Utility, Richard M. EglenNMDA Receptor Antagonists, John A. Kemp and James N. C. KewNew Trends in Drug Design Computational Chemistry in Receptor-Based Drug Design, Ad P. IJzerman, Eleonora M. van der Wenden, and Wilma KuipersRecombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery, A. Donny Strosberg and Prabhavathi B. FernandesInverse Agonists and G-Protein-Coupled Receptors, Richard A. Bond and Michel Bouvier

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