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eberhardt manfred k. - reactive oxygen metabolites
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Reactive Oxygen Metabolites Chemistry and Medical Consequences




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Dettagli

Genere:Libro
Lingua: Inglese
Editore:

CRC Press

Pubblicazione: 07/2000
Edizione: 1° edizione





Trama

In recent years, the field of radical chemistry has undergone explosive growth. Although its roots lie in organic chemistry, the implications of its findings are having enormous impact in a broad range of disciplines, and we now have evidence for radical involvement in over 100 diseases. As important as this is, however, the subject of radicals and reactive oxygen metabolites (ROMs) is complex and barely touched upon in the curriculum of medical schools. Reactive Oxygen Metabolites brings the subject within the grasp of even those with little preparation in chemistry. From the basic chemistry of radicals through the pathology, the author provides a clear and thorough introduction to ROMs and their importance to human health and disease. Exhaustively researched and referenced, this highly readable work will give you the ability to critically analyze and evaluate many pathological problems arising from the chemistry of ROMs and reduce them to their lowest common denominator. It is the ideal vehicle for people who need to understand the importance of reactive oxygen and nitrogen species in human health and disease but have neither the time, the inclination, nor perhaps the background to work their way through the mountain of original literature.




Sommario

THE PROS AND CONS OF LIVING IN AN OXYGEN ATMOSPHEREBASIC CHEMISTRY OF RADICALSDefinition and HistoryFormation of RadicalsReactions of RadicalsCHEMISTRY OF OXYGEN-DERIVED RADICALSHistorical PerspectiveDefinitionsOne-Electron Reduction of OxygenSuperoxide Radical AnionPeroxyl RadicalsHydroxyl RadicalCHEMISTRY OF ELECTRONICALLY EXCITED STATESSinglet OxygenExcited Carbonyl CompoundsFORMATION OF REACTIVE OXYGEN METABOLITES IN VIVOIntroductionMitochondrial Electron TransportHemoproteinsFlavin-Linked OxidasesThe Microsomal Enzymme SystemPhagocytosisElectronically Excited CarbonylCompounds via Enzymatic OxidationsEndothelium-Derived Relaxing Factor (EDRF)REACTIONS OF REACTIVE OXYGEN METABOLITES WITH IMPORTANT BIOMOLECULESGeneral Remarks about Oxygen Radical InvestigationsReactions of Hydroxyl Radicals with Fatty AcidsMechanism of Lipid Peroxidation-Induced PathogenesisChemistry of Oxygen Radical Damage to DNADNA Damage via Electronically Excited StatesBiological Markers for in vivo Oxidative DamageNITRIC OXIDEChemical Formation of Nitric OxideChemistry of Nitric OxideImportant Reactions in the Deactivation of Nitric OxideReactions of Nitrogen DioxideNitric Oxide and Superoxide DismutaseThe Chemical Nature of EDRFChemistry of Peroxynitrite-Peroxynitrous AcidThe Role of Peroxzynitrite-Peroxynitrous Acid in vivoProtective Effect of Nitric Oxide in Oxygen Radical Induced DamageToxicity of Nitric Oxide via Release of Fe(II) from FerritinProtein Derived Radicals and Nitric OxideANTIOXIDANTSIntroductionSuperoxide DismutasesReactions of Oxygen and Oxygen Radicals with Ascorbic AcidUric AcidMelatoninVitamin EAntioxidan and Prooxidant Activity of FlavonoidsCarotenoidsProteins which form Complexes with Transition-Metal IonsPeptides as AntioxidantsDo Antioxidants Prevent Diseases in vivo?PATHOLOGICAL PROCESSES INVOLVING REACTIVE OXYGEN METABOLITESIntroductionAging and CancerInflammation, Cell Division, and CancerNeurodegenerative DisordersLung DiseasesAtherosclerosisIschemia-ReperfusionOxidative Stress and LifestyleCONCLUSIONREFERENCES










Altre Informazioni

ISBN:

9780849308918

Condizione: Nuovo
Dimensioni: 9.25 x 6.25 in Ø 2.22 lb
Formato: Copertina rigida
Illustration Notes:100 b/w images and 3 tables
Pagine Arabe: 608


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