1. Introduction 2. Quine’s Philosophical Background: Beginnings; Logic; Carnap 3. The Analytic-synthetic Distinction 4. Re-conceiving Epistemology 5. The Beginnings of Cognitive Language: Shared Responses to Stimulation and Observation Sentences 6. Beyond the Observation Sentences 7. Theory and Evidence 8. Radical Translation and its Indeterminacy 9. Quinean Metaphysics: Limning the Structure of Reality 10. A Framework for Theory: the Role of Logic 11. Extensionality, Reference, and Singular Terms 12. Ontology, Physicalism, Realism 13. Minds, Beliefs, and Modality. Conclusion. Index