Precision Approaches to Heterogeneity in Asthma

Introduction Part I.- The spectrum of asthma epidemiology.- Disease prevalence and burden.- Climate considerations in asthma and impacts of climate change.- Asthma across the ages: children, women, and the elderly.- Asthma as a systemic disease: neurologic, cardiac and metabolic changes in asthma.- Social determinants of health in asthma.- Part II. Mechanistic heterogeneity in asthma, -Phenotypes and endotypes.- Heterogeneity of treatment response to asthma (including mild-moderate asthma).- Regional airway involvement: Imaging heterogeneity in ventilation, mucus and remodeling.- Biobehavioral determinants of asthma, including CNS influences and dietary/nutrition.- Integrative/ Systems levels studies.- Part III. Severe and difficult to treat asthma endotypes.- Definition, phenotyping of severe asthma, including cluster analysis.- Asthma exacerbations: patient features and potential long-term implications.- Innate inflammation driven remodeling.- Adaptive immunity and remodeling.- PartIV. Influence of heterogeneity on approaches to management.- Approaches to management of asthma.- Guidelines for stepped care and self-monitoring.- Global considerations in asthma treatment - management in low resource settings.- Update on biomarker-driven approaches and precision medicine- adaptive clinical trials e.g., PRECISE.- Conclusion and future directions.