Porous Silicon for Biomedical Applications, Second Edition, provides an updated guide to the diverse range of biomedical applications of porous silicon, from biosensing and imaging to tissue engineering and cancer therapy.
Across biomedical disciplines, there is an ongoing search for biomaterials that are biocompatible, modifiable, structurally sound, and versatile. Porous silicon possesses a range of properties that make it ideal for a variety of biomedical applications, such as controllable geometry, tunable nanoporous structure, large pore volume/high specific surface area, and versatile surface chemistry.
This book provides a fully updated and detailed overview of the range of biomedical applications for porous silicon. Part One offers the reader a helpful insight into the fundamentals and beneficial properties of porous silicon, including thermal properties and stabilization, photochemical and nonthermal chemical modification, protein modification, and biocompatibility. The book then builds on the systematic detailing of each biomedical application using porous silicon, from bioimaging and sensing to drug delivery and tissue engineering. This new edition also includes new chapters on in-vivo assessment of porous silicon, photodynamic and photothermal therapy, micro- and nanoneedles, Raman imaging, cancer immunotherapy, and more.
With its acclaimed editor and international team of expert contributors, Porous Silicon for Biomedical Applications, Second Edition, is a technical resource and indispensable guide for all those involved in the research, development, and application of porous silicon and other biomaterials, while providing a comprehensive introduction for students and academics interested in this field.
Introduction H.A. Santos Part I: Fundamentals of porous silicon for biomedical applications 1. Thermal stabilization of porous silicon J. Salonen and E. Mäkilä 2. Thermal properties of nanoporous silicon materials N. Koshida 3. Photochemical and nonthermal chemical modification of porous silicon K.W. Kolasinski 4. Protein-modified porous silicon optical devices for biosensing M. Terracciano, C. Tramontano, R. Moretta, B. Miranda, N. Borbone, L. De Stefano, and I. Rea 5. Biocompatibility of porous silicon I.S. Naiyeju and L.M. Bimbo
Part II: Porous silicon for bioimaging and biosensing applications 6. Optical properties of porous silicon materials V. Torres-Costa and R.J. Martín-Palma 7. Radiolabeled porous silicon for nuclear imaging and theranostic applications M. Sarparanta and A.J. Airaksinen 8. Porous silicon for targeting microorganisms: Detection and treatment N. Massad-Ivanir, S. Arshavsky-Graham, and E. Segal 9. Porous silicon biosensors for DNA sensing G.A. Rodriguez, J.L. Lawrie, R. Layouni, and S.M. Weiss 10. Near-infrared imaging for in vivo assessment of porous silicon-based materials B. Xia, J. Li, and Y. Gao 11. Porous silicon-based sensors for protein detection E.E. Antunez, M.A. Martin, and N.H. Voelcker
Part III: Porous silicon for drug delivery, cancer therapy, and tissue engineering applications 12. Nanoporous silicon to enhance oral delivery of poorly water-soluble drugs H.B. Schultz, P. Joyce, C.A. Prestidge, and T.J. Barnes 13. Porous silicon for tumor targeting and imaging J.-H. Park, M. Jeong, and H. Kim 14. Porous silicon-polymer composites for cell culture and tissue engineering S.J.P. McInnes, R.B. Vasani, N.K. McMillan, and N.H. Voelcker 15. Porous silicon and related composites as functional tissue engineering scaffolds N.K. McMillan and J.L. Coffer 16. Porous silicon in photodynamic and photothermal therapy L.A. Osminkina and M.B. Gongalsky 17. Porous silicon microneedles and nanoneedles for biomedical applications C. Chiappini 18. Porous silicon materials for cancer and immunotherapy F. Fontana, Z. Liu, J. Hirvonen, and H.A. Santos